新网格型 Compass 眼底周边视野计与 10-2 测试方案检测中心视野缺损的一致性。
Agreement between Compass Fundus Perimeter New Grid and 10-2 Testing Protocols for Detecting Central Visual Field Defects.
机构信息
Hamilton Glaucoma Center, Shiley Eye Institute, and the Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California.
Hamilton Glaucoma Center, Shiley Eye Institute, and the Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California.
出版信息
Ophthalmol Glaucoma. 2022 Mar-Apr;5(2):179-187. doi: 10.1016/j.ogla.2021.07.006. Epub 2021 Jul 20.
PURPOSE
To evaluate the agreement between Compass New Grid (NG) and 10-2 test protocols for detecting early glaucomatous defects in the central 10 degrees of the visual field (CVFD).
DESIGN
Cross-sectional study.
PARTICIPANTS
A total of 123 eyes of 14 healthy individuals, 17 glaucoma suspects, and 32 glaucoma patients were enrolled.
METHODS
Subjects performed NG and 10-2 Compass automated perimetry testing within 1 week. For both test protocols, total deviation (TD) and pattern deviation (PD) plot CVFDs were defined by 3 contiguous points with probabilities of <5%, <2%, <2% or <5%, <1%, <1%. Cohen's Kappa statistic was used to assess agreement between NG and 10-2 for identifying CVFDs. The Spectralis GMPE Hood Glaucoma Report (investigational software version) macula deviation analysis obtained within 1 year was used for calculating sensitivities and specificities of test protocols.
MAIN OUTCOME MEASURES
Protocols' agreement, sensitivity, and specificity.
RESULTS
Fair to moderate agreement was observed between NG and 10-2 protocols for detecting presence of superior CVFDs on TD (k = 0.57) and PD (k = 0.26) plots and for detecting inferior CVFDs on TD (0.49) and PD (0.27) plots. With the use of OCT macula deviation maps, specificity for detecting CVFD was consistently higher with NG than 10-2 tests for TD plots of the superior hemifield (0.82 and 0.65), inferior hemifield (0.92 and 0.84), and PD plots of the superior hemifield (0.81 and 0.36) and inferior hemifield (0.86 and 0.52). Sensitivity of NG was consistently lower than TD plots of the superior hemifield (0.48 and 0.72), inferior hemifield (0.28 and 0.46), and PD plots of the superior hemifield (0.48 and 0.78) and inferior hemifield (0.20 and 0.52). By using pattern standard deviation (PSD) criterion, the mean PSD values for 10-2 and NG VF tests were 1.61 (95% confidence interval [CI], 1.26-1.96) and 1.81 (95% CI, 1.45-2.17) (P < 0.001), respectively.
CONCLUSIONS
Although the Compass NG detected fewer CVFDs than the 10-2 test protocol, it did detect CVFDs that were not observed in the Compass 24-2 test in patients with early glaucoma. Therefore, NG may be particularly useful in clinical situations when higher specificity is desired or PSD criterion is used.
目的
评估 Compass New Grid（NG）与 10-2 测试协议在检测中央 10 度视野（CVFD）早期青光眼缺陷方面的一致性。
设计
横断面研究。
参与者
共纳入 14 名健康个体、17 名青光眼疑似患者和 32 名青光眼患者的 123 只眼。
方法
受试者在 1 周内进行 NG 和 10-2 Compass 自动视野检查。对于这两种测试方案，总偏差（TD）和模式偏差（PD）图的 CVFD 由概率 <5%、<2%、<2%或 <5%、<1%、<1%的 3 个连续点定义。使用 Cohen's Kappa 统计评估 NG 和 10-2 之间识别 CVFD 的一致性。在 1 年内使用 Spectralis GMPE Hood 青光眼报告（研究软件版本）黄斑偏差分析来计算测试方案的敏感性和特异性。
主要观察指标
协议的一致性、敏感性和特异性。
结果
在 TD（k=0.57）和 PD（k=0.26）图上检测上半视野 CVFD 的存在以及在 TD（0.49）和 PD（0.27）图上检测下半视野 CVFD 的存在方面，NG 和 10-2 协议之间观察到了良好到中度的一致性。使用 OCT 黄斑偏差图，与 10-2 测试相比，NG 检测 CVFD 的特异性始终更高，用于上半视野的 TD 图（0.82 和 0.65）、下半视野（0.92 和 0.84）以及 PD 图的上半视野（0.81 和 0.36）和下半视野（0.86 和 0.52）。NG 的敏感性始终低于上半视野 TD 图（0.48 和 0.72）、下半视野（0.28 和 0.46）以及 PD 图的上半视野（0.48 和 0.78）和下半视野（0.20 和 0.52）。使用模式标准差（PSD）标准，10-2 和 NG VF 测试的平均 PSD 值分别为 1.61（95%置信区间[CI]，1.26-1.96）和 1.81（95% CI，1.45-2.17）（P<0.001）。
结论
尽管 Compass NG 检测到的 CVFD 比 10-2 测试协议少，但它确实检测到了在早期青光眼患者的 Compass 24-2 测试中未观察到的 CVFD。因此，当需要更高的特异性或使用 PSD 标准时，NG 可能特别有用。
Zotero 插件