Cazals Y, Erre J P, Aurousseau C
Laboratoire d'Audiologie Expérimentale, INSERM unité 229, Université Bordeaux II, Hôpital Pellegrin, France.
Hear Res. 1987 Nov;31(1):93-7. doi: 10.1016/0378-5955(87)90216-4.
Anatomical and physiological studies of brainstem acoustic nuclei involving the classical ascending auditory pathway or the cerebellar and reticular pathways imply that all afferents from the cochlea terminate in the cochlear nucleus. In the experimental pathology of complete and selective destruction of the cochlea in the guinea pig acoustic responses still evoked at mid and high intensities, demonstrated to come from the saccule, show a pattern of far field evoked brainstem potentials quite different from that of normal animals. Intracranial electrophysiological investigations of the brainstem were undertaken in such pathological animals and in normal guinea pigs for comparison. In both cases acoustic responses were recorded at the base of the vestibular nucleus, showing a first peak corresponding to an eighth nerve projection and after a synaptic delay a second peak of local activation. In normal animals acoustic responses from the vestibular nucleus showing normal threshold and tuning curves may represent a direct projection from the cochlea.
对涉及经典听觉上行通路或小脑及网状通路的脑干听觉核的解剖学和生理学研究表明，来自耳蜗的所有传入神经都终止于耳蜗核。在豚鼠耳蜗完全和选择性破坏的实验病理学中，在中高强度下仍能诱发听觉反应，已证明这些反应来自球囊，其远场诱发脑干电位模式与正常动物有很大不同。对这类病理动物和正常豚鼠进行了脑干的颅内电生理研究以作比较。在这两种情况下，都在前庭核底部记录到听觉反应，显示出第一个峰值对应于第八神经投射，经过突触延迟后出现局部激活的第二个峰值。在正常动物中，前庭核的听觉反应显示出正常的阈值和调谐曲线，可能代表来自耳蜗的直接投射。
