Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori Mizuhoku, Nagoya, 467-8603, Japan.
Department of Physiology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan; Department of Pharmacy, College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori Moriyamaku, Nagoya, 463-8521, Japan.
J Pharmacol Sci. 2021 Sep;147(1):81-85. doi: 10.1016/j.jphs.2021.05.012. Epub 2021 Jun 5.
Pulmonary arterial hypertension (PAH) is a rare, progressive, and fatal cardiovascular/lung disease. The incidence rate is affected by age. Monocrotaline (MCT, 60 mg/kg)-treated rats are widely used as an experimental PAH model. Here, we found that young rats died at a mean of 23.4 days after MCT injection, whereas adult rats survived for over 42 days. However, young (7-week-old) and adult (20-week-old) MCT-treated rats developed PAH, and had upregulated Ca-sensing receptor and transient receptor potential canonical subfamily 6 channel expression in pulmonary arteries. The present study provides novel information for elucidating the mechanism underlying the age difference in PAH patients.
肺动脉高压（PAH）是一种罕见的、进行性的、致命的心血管/肺部疾病。其发病率受年龄影响。野百合碱（MCT，60mg/kg）处理的大鼠被广泛用作实验性 PAH 模型。在这里，我们发现，MCT 注射后，年轻大鼠平均在 23.4 天内死亡，而成年大鼠则存活超过 42 天。然而，年轻（7 周龄）和成年（20 周龄）MCT 处理的大鼠发展为 PAH，并且肺血管中钙敏感受体和瞬时受体电位经典亚家族 6 通道的表达上调。本研究为阐明 PAH 患者年龄差异的机制提供了新的信息。
