Huiskes R, Weinans H, Grootenboer H J, Dalstra M, Fudala B, Slooff T J
Institute of Orthopaedics, University of Nijmegen, The Netherlands.
J Biomech. 1987;20(11-12):1135-50. doi: 10.1016/0021-9290(87)90030-3.
The subject of this article is the development and application of computer-simulation methods to predict stress-related adaptive bone remodeling, in accordance with 'Wolff's Law'. These models are based on the Finite Element Method (FEM) in combination with numerical formulations of adaptive bone-remodeling theories. In the adaptive remodeling models presented, the Strain Energy Density (SED) is used as a feed-back control variable to determine shape or bone density adaptations to alternative functional requirements, whereby homeostatic SED distribution is assumed as the remodeling objective. These models are applied to investigate the relation between 'stress shielding' and bone resorption in the femoral cortex around intramedullary prostheses, such as used in Total Hip Arthroplasty (THA). It is shown that the amount of bone resorption depends mainly on the rigidity and the bonding characteristics of the implant. Homeostatic SED can be obtained when the resorption process occurs at the periosteal surface, rather than inside the cortex, provided that the stem is adequately flexible.
本文的主题是根据“沃尔夫定律”，开发并应用计算机模拟方法来预测与应力相关的适应性骨重塑。这些模型基于有限元法（FEM），并结合了适应性骨重塑理论的数值公式。在所提出的适应性重塑模型中，应变能密度（SED）被用作反馈控制变量，以确定形状或骨密度对不同功能需求的适应性，从而将稳态SED分布假定为重塑目标。这些模型被用于研究髓内假体周围股骨皮质中的“应力屏蔽”与骨吸收之间的关系，如全髋关节置换术（THA）中所使用的假体。结果表明，骨吸收量主要取决于植入物的刚度和结合特性。只要假体柄具有足够的柔韧性，当骨吸收过程发生在骨膜表面而非皮质内部时，就可以获得稳态SED。
