优化交界性和局部进展期胰腺癌的治疗路径：一种适应性个体化方法。
Optimising treatment pathways for borderline and locally advanced pancreatic cancer: an adaptive personalised approach.
机构信息
Consultant Clinical Oncologist, The Christie Hospital, Manchester, UK.
Professor of Surgery, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
出版信息
Br J Cancer. 2021 Oct;125(9):1179-1180. doi: 10.1038/s41416-021-01416-8. Epub 2021 Jul 22.
Abstract
The treatment paradigm for borderline and locally advanced pancreatic cancer is evolving with an increased shift towards utilising systemic chemotherapy and chemoradiation to potentially facilitate more curative resections. This has been driven by the improved outcomes from the use systemic combination chemotherapy on its own, or sequentially with chemoradiation, resulting in improved resection rates and survival outcomes.
摘要
对于交界性和局部进展期胰腺癌，其治疗模式正在发生变化，越来越倾向于采用全身化疗和放化疗，以促进更具根治性的手术切除。这是由于全身联合化疗或序贯放化疗的应用改善了患者的预后，提高了手术切除率和生存结局。
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本文引用的文献
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JAMA Oncol. 2021 May 1;7(5):735-738. doi: 10.1001/jamaoncol.2021.0057.
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Preoperative Chemoradiotherapy Versus Immediate Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Results of the Dutch Randomized Phase III PREOPANC Trial.可切除及临界可切除胰腺癌的术前放化疗与直接手术对比：荷兰随机III期PREOPANC试验结果
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The role of induction chemotherapy + chemoradiotherapy in localised pancreatic cancer: initial experience in Scotland.诱导化疗+放化疗在局部胰腺癌中的作用：苏格兰的初步经验。
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Long-term results and recurrence patterns from SCALOP: a phase II randomised trial of gemcitabine- or capecitabine-based chemoradiation for locally advanced pancreatic cancer.SCALOP的长期结果和复发模式：一项关于吉西他滨或卡培他滨为基础的同步放化疗治疗局部晚期胰腺癌的II期随机试验
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