Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Psychology, Pediatric Multi-Organ Transplant Program, BC Children's Hospital, Vancouver, BC, Canada.
Pediatr Transplant. 2021 Dec;25(8):e14093. doi: 10.1111/petr.14093. Epub 2021 Jul 22.
Physical activity (PA) has been shown to have benefits, including improving health-related quality of life (HRQOL). However, there are few and conflicting studies assessing PA and its relationship with HRQOL in a pediatric solid-organ transplant (SOT) population. The aim of this study was to assess whether overall HRQOL was associated with PA and to determine whether that association was independent of other baseline and contemporaneous clinical and demographic indicators.
A retrospective cross-sectional review was performed on 55 pediatric transplant patients (13 heart, 27 kidney, and 15 liver transplant). PA was measured by PAQ-C/PAQ-A, and HRQOL was measured using PedsQL. Demographics, baseline, and contemporaneous data were collected.
There were no significant differences in baseline and contemporaneous characteristics between heart, kidney, and liver transplant recipients. SOT recipients were 15.0 (11.0-18.0) years old at completion of surveys. Median PAQ score was 2.3 (1.6-3.2), PedsQL total score was 77 (65-91), and PedsQL physical functioning score was 88 (72-97). The PedsQL total score was not significantly associated with PAQ score. The PAQ score was significantly associated with physical functioning subscore of the PedsQL (r = 0.37, p < 0.01). Higher physical functioning score was associated with time since transplant (r = 0.29, p = 0.031).
Our SOT cohort has a HRQOL similar to other chronic conditions and higher than previous reported HRQOL in pediatric SOT populations. Higher levels of PA and longer time since transplant are associated with higher physical functioning scores.
已有研究表明，身体活动（PA）对健康相关生活质量（HRQOL）有益，包括提高 HRQOL。然而，评估儿科实体器官移植（SOT）人群中 PA 及其与 HRQOL 关系的研究很少且相互矛盾。本研究旨在评估整体 HRQOL 是否与 PA 相关，并确定该相关性是否独立于其他基线和同期临床及人口统计学指标。
对 55 名儿科移植患者（13 例心脏、27 例肾脏和 15 例肝脏移植）进行回顾性横断面研究。PA 通过 PAQ-C/PAQ-A 进行测量，HRQOL 通过 PedsQL 进行测量。收集人口统计学、基线和同期数据。
心脏、肾脏和肝脏移植受者的基线和同期特征无显著差异。SOT 受者完成调查时年龄为 15.0（11.0-18.0）岁。PAQ 评分中位数为 2.3（1.6-3.2），PedsQL 总分 77（65-91），PedsQL 生理功能评分 88（72-97）。PedsQL 总分与 PAQ 评分无显著相关性。PAQ 评分与 PedsQL 生理功能子评分显著相关（r=0.37，p<0.01）。较高的生理功能评分与移植时间呈正相关（r=0.29，p=0.031）。
我们的 SOT 队列的 HRQOL 与其他慢性疾病相似，高于先前报道的儿科 SOT 人群的 HRQOL。较高的 PA 水平和较长的移植时间与较高的生理功能评分相关。
