基于生物标志物的内脏脂肪评分与多种族队列中 2 型糖尿病的发生。
Biomarker-based visceral adiposity score and incident type 2 diabetes in the multiethnic cohort.
机构信息
University of Hawaii Cancer Center, Honolulu, HI.
Keck School of Medicine, University of Southern California, Los Angeles, CA.
出版信息
Ann Epidemiol. 2021 Nov;63:29-34. doi: 10.1016/j.annepidem.2021.07.002. Epub 2021 Jul 21.
PURPOSE
Visceral adipose tissue (VAT) may be more important than subcutaneous fat in type 2 diabetes (T2D) etiology. We examined a VAT score developed in reference to MRI measurement of VAT in the Multiethnic Cohort (MEC) as a risk factor for incident T2D.
METHODS
Two nested case-control studies of cancer allowed calculation of the VAT score based on anthropometric measures and 8 biomarkers among 2,556 participants without T2D. Incident cases were identified from Medicare linkages and self-reports after blood draws in 2001-2006. Cox regression with age as time metric was applied to estimate the association of the VAT score with T2D.
RESULTS
During 10.1 ± 2.4 years, 355 incident T2D cases were identified. VAT scores were higher in T2D cases than among those without disease (5.06±0.43 vs. 4.95±0.41; P<0.0001) and significantly associated with T2D (HR = 2.70; 95%CI 1.60, 4.58 per unit) with similar values in men (HR = 2.99; 95%CI 1.03, 8.73) and women (HR = 2.61; 95%CI 1.39, 4.91). A significant association was observed in all five ethnic groups but only statistically significant among Japanese Americans (HR = 6.24; 95%CI 2.34, 16.68).
CONCLUSION
These findings support that VAT as estimated by a biomarker-based score predicts T2D incidence beyond BMI in particular among older adults of Japanese ancestry.
目的
内脏脂肪组织（VAT）在 2 型糖尿病（T2D）发病机制中的重要性可能超过皮下脂肪。我们研究了一种基于多民族队列（MEC）中 MRI 测量 VAT 的方法得出的 VAT 评分，作为 T2D 发病的危险因素。
方法
在两个无 T2D 的癌症病例对照嵌套研究中，根据人体测量指标和 8 种生物标志物，对 2556 名参与者进行了 VAT 评分计算。通过医疗保险关联和 2001-2006 年采血后的自我报告，确定了发病病例。年龄作为时间度量的 Cox 回归用于估计 VAT 评分与 T2D 的关联。
结果
在 10.1±2.4 年的随访期间，发现了 355 例 T2D 发病病例。T2D 病例的 VAT 评分高于无疾病者（5.06±0.43 与 4.95±0.41；P<0.0001），并且与 T2D 显著相关（HR=2.70；95%CI 1.60，4.58 每单位），男性（HR=2.99；95%CI 1.03，8.73）和女性（HR=2.61；95%CI 1.39，4.91）的值相似。在所有五个种族群体中均观察到显著相关性，但仅在日裔美国人中具有统计学意义（HR=6.24；95%CI 2.34，16.68）。
结论
这些发现支持了基于生物标志物评分估计的 VAT 预测 T2D 发病的作用，特别是在年龄较大的日裔成年人中，其作用超过 BMI。
Zotero 插件