Fujibayashi Y, Haendchen R V, Uchiyama T, Kajiwara N, Meerbaum S, Corday E
Second Department of Internal Medicine, Surugadai Nihon University School of Medicine, Surugadai Nihon University Hospital, Tokyo.
J Cardiogr. 1986 Dec;16(4):809-17.
Two-dimensional echocardiography (2DE) was performed in nine dogs with three hour proximal occlusion of the left anterior descending coronary artery and seven day reperfusion for sequentially mapping systolic functions (Seg-FAC%: percent segmental fractional area change) and diastolic functions (Seg-VLAC: mean velocity of segmental luminal area change) of eight segments in a mid-papillary left ventricular short-axis cross-section. The corresponding segment functions on 2DE to the most profoundly affected segment were evaluated by triphenyl-tetrazolium-chloride staining seven days post reperfusion, and categorized in two groups in terms percent mural necrosis (N%): N% greater than or equal to 40% in group A and N% less than 40% in group B, respectively. Seg-FAC% showed a significant difference between the two groups seven days post reperfusion (13.4 +/- 9.4% in group A, 53.3 +/- 7.7% in group B), while Seg-VLAC showed significant differences in the groups at three hours post occlusion (-1.6 +/- 2.1 cm2/sec in group A and 3.2 +/- 2.6 cm2/sec in group B) and seven days post reperfusion (0.48 +/- 4.7 cm2/sec in group A and 7.5 +/- 2.4 cm2/sec in group B). At seven days post reperfusion, Seg-VLAC correlated negatively with N% (r = -0.94), while Seg-FAC% did not with N% (r = -0.58). It was concluded that Seg-VLAC, after three hours' occlusion, predicts the recovery of the regional left ventricular function seven days after reperfusion; and Seg-VLAC, seven days after reperfusion can estimate the regional transmurality of necrosis thereafter.
对9只犬进行二维超声心动图（2DE）检查，这些犬左前降支冠状动脉近端闭塞3小时，再灌注7天，以依次绘制左心室乳头肌水平短轴切面8个节段的收缩功能（节段分数面积变化百分比：Seg-FAC%）和舒张功能（节段腔面积变化平均速度：Seg-VLAC）。再灌注7天后，通过氯化三苯基四氮唑染色评估2DE上与受影响最严重节段相对应的节段功能，并根据壁坏死百分比（N%）分为两组：A组N%大于或等于40%，B组N%小于40%。再灌注7天后，两组之间Seg-FAC%存在显著差异（A组为13.4±9.4%，B组为53.3±7.7%），而Seg-VLAC在闭塞3小时时两组之间存在显著差异（A组为-1.6±2.1 cm2/秒，B组为3.2±2.6 cm2/秒）以及再灌注7天后（A组为0.48±4.7 cm2/秒，B组为7.5±2.4 cm2/秒）。再灌注7天时，Seg-VLAC与N%呈负相关（r = -0.94），而Seg-FAC%与N%无相关性（r = -0.58）。得出的结论是，闭塞3小时后，Seg-VLAC可预测再灌注7天后左心室局部功能的恢复；再灌注7天后，Seg-VLAC可估计此后局部坏死的透壁程度。
