Oshima K, Matsumoto K, Akimoto A, Tsuda T, Sasada M
Department of Physiology, Kyoto University, Aichi.
Nihon Sanka Fujinka Gakkai Zasshi. 1987 Nov;39(11):2036-42.
Effects of prostaglandins and their analogues in reproduction were investigated using rats and Japanese monkeys. Prostaglandin of the F series exerted uterine contractile, luteolytic, anti-nidation and abortifacient effects. Prostaglandins of the E series exhibited a potent uterine contractile effect, although their luteolytic, anti-nidation and abortifacient effects were much less potent than those of the PGF series. A comparison of animal and human data on prostaglandins and their analogues indicated a good cor-relationship between the uterine contractile effect in animals (rates and monkeys) and the abortifacient or labor inducing effect in humans.
使用大鼠和日本猕猴研究了前列腺素及其类似物在生殖方面的作用。F 系列前列腺素具有子宫收缩、黄体溶解、抗着床和堕胎作用。E 系列前列腺素表现出强大的子宫收缩作用，尽管它们的黄体溶解、抗着床和堕胎作用比 PGF 系列弱得多。动物和人类关于前列腺素及其类似物的数据比较表明，动物（大鼠和猕猴）的子宫收缩作用与人类的堕胎或引产作用之间存在良好的相关性。
