Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, Wisconsin.
Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Pediatr Neurol. 2021 Sep;122:68-75. doi: 10.1016/j.pediatrneurol.2021.06.003. Epub 2021 Jun 17.
Changes in cerebral blood flow in response to neuronal activation can be measured by time-dependent fluctuations in hemoglobin species within the brain; this is the basis of functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS). There is a clinical need for portable neural imaging systems, such as fNIRS, to accommodate patients who are unable to tolerate an MR environment.
Our objective was to compare task-related full-head fNIRS and fMRI signals across cortical regions.
Eighteen healthy adults completed a same-day fNIRS-fMRI study, in which they performed right- and left-hand finger tapping tasks and a semantic-decision tones-decision task. First- and second-level general linear models were applied to both datasets.
The finger tapping task showed that significant fNIRS channel activity over the contralateral primary motor cortex corresponded to surface fMRI activity. Similarly, significant fNIRS channel activity over the bilateral temporal lobe corresponded to the same primary auditory regions as surface fMRI during the semantic-decision tones-decision task. Additional channels were significant for this task that did not correspond to surface fMRI activity.
Although both imaging modalities showed left-lateralized activation for language processing, the current fNIRS analysis did not show concordant or expected localization at the level necessary for clinical use in individual pediatric epileptic patients. Future work is needed to show whether fNIRS and fMRI are comparable at the source level so that fNIRS can be used in a clinical setting on individual patients. If comparable, such an imaging approach could be applied to children with neurological disorders.
通过测量大脑内血红蛋白随时间的波动，可以检测到神经元激活时的脑血流变化，这是功能磁共振成像（fMRI）和功能近红外光谱（fNIRS）的基础。临床需要便携式神经成像系统，如 fNIRS，以适应无法耐受磁共振环境的患者。
我们的目标是比较全头 fNIRS 和 fMRI 信号在皮质区域的相关性。
18 名健康成年人完成了同日的 fNIRS-fMRI 研究，他们在研究中执行右手和左手手指敲击任务以及语义决策音决策任务。对两个数据集都应用了一阶和二阶广义线性模型。
手指敲击任务显示，对侧初级运动皮层的显著 fNIRS 通道活动与表面 fMRI 活动相对应。同样，在语义决策音决策任务中，双侧颞叶的显著 fNIRS 通道活动与表面 fMRI 的相同初级听觉区域相对应。对于这个任务，还有其他一些通道的信号也很显著，但与表面 fMRI 活动不对应。
尽管两种成像模式都显示出语言处理的左侧激活，但当前的 fNIRS 分析没有显示出与临床用于个体癫痫患者所需的水平相匹配或预期的定位。需要进一步的工作来表明 fNIRS 和 fMRI 在源水平上是否具有可比性，以便 fNIRS 可以在个体患者的临床环境中使用。如果可以比较，这种成像方法可以应用于患有神经障碍的儿童。
