Lindenberg J A, Milstein J M, Cox K L
Department of Pediatrics, School of Medicine, University of California, Davis 95616.
J Pediatr Gastroenterol Nutr. 1987 May-Jun;6(3):474-6.
We cared for four neonates with transient hyperammonemia of the newborn (THAN), all of whom exhibited sclerema during their course. Sclerema is a hardening of the subcutaneous tissues, which gives the tissue a firm, rubber-like quality. This association has not been previously reported, and it may provide a clue to early diagnosis and intervention in THAN.