Ronald O. Perelman Department of Dermatology, NYU Langone Health, New York, New York, USA.
Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
J Invest Dermatol. 2021 Sep;141(9):2112-2122.e3. doi: 10.1016/j.jid.2021.02.764. Epub 2021 Jul 22.
Psoriasis is a chronic inflammatory condition characterized by systemic immune dysregulation. Over the past several years, advances in genetics, microbiology, immunology, and mouse models have revealed the complex interplay between the heritable and microenvironmental factors that drive the development of psoriatic inflammation. In the first of this two-part review series, the authors will discuss the newest insights into the pathogenesis of psoriatic disease and highlight how the evolution of these scientific fields has paved the way for a more personalized approach to psoriatic disease treatment.
银屑病是一种慢性炎症性疾病,其特征为全身免疫失调。在过去的几年中,遗传学、微生物学、免疫学和小鼠模型方面的进展揭示了遗传和微环境因素之间的复杂相互作用,这些因素推动了银屑病炎症的发展。在这篇由两部分组成的综述系列的第一部分中,作者将讨论银屑病发病机制的最新见解,并强调这些科学领域的发展如何为银屑病治疗的个体化方法铺平了道路。