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[2012年至2019年加那利群岛多重耐药微生物和艰难梭菌感染发病率密度的前瞻性研究]

[Prospective study of the incidence density of multi-resistant microorganisms and Clostridioides difficile during the period 2012- 2019 in the Canary Islands].

作者信息

de Arriba-Fernández A, Molina-Cabrillana M J, Serra-Majem L, García-de Carlos P

机构信息

Alejandro de Arriba-Fernández, Universidad de Las Palmas de Gran Canaria. Paseo Blas Cabrera Felipe "Físico", 310, CP: 35016. Las Palmas Gran Canaria. Spain.

出版信息

Rev Esp Quimioter. 2021 Oct;34(5):483-490. doi: 10.37201/req/046.2021. Epub 2021 Jul 26.

DOI:10.37201/req/046.2021
PMID:34304433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8638839/
Abstract

OBJECTIVE

In 2012, the Canary Islands Health Service implemented a new surveillance system for nosocomial infections caused by multi-resistant microorganisms and Clostridioides difficile. This system will make it possible to know the incidence rates of these pathogens, periodically contrast them to monitor their trend and compare them with those of other national and European health institutions.

METHODS

Observational, prospective study of the density of incidence of multi-resistant pathogens and Clostridioides difficile in the healthcare centers of the Canary Islands Health Service from 2012 to 2019.

RESULTS

The incidence density of methicillin-resistant Staphylococcus aureus infections for 2012 was 1.96 cases per 10,000 stays and decreased to 0.80 in 2019, reaching the lowest figure in the surveillance period. Infections due to carbapenemase-producing Enterobacterales (CPE) showed an upward trend, 0.47 (2014) and 2.35 (2019). The slight upward trend in imipenem-resistant Acinetobacter baumannii infections in observed bacteraemias 0.17 (2012) and 0.09 (2019) has been corrected. No cases of infection with vancomycin-resistant enterococci were observed. With regard to C. difficile, an upward trend that began in 2012 has consolidated, producing an increase of 216% in the number of cases detected at the end of the study period.

CONCLUSIONS

The most relevant problem detected today is the CPE. The data analyzed in this period showed an evident change in the trend of the multi-resistant pathogens studied. This fact must be confirmed in the future.

摘要

目的

2012年，加那利群岛卫生服务局实施了一项针对多重耐药微生物和艰难梭菌引起的医院感染的新监测系统。该系统将能够了解这些病原体的发病率，定期进行对比以监测其趋势，并与其他国家和欧洲卫生机构的发病率进行比较。

方法

对2012年至2019年加那利群岛卫生服务局医疗中心多重耐药病原体和艰难梭菌的发病密度进行观察性前瞻性研究。

结果

2012年耐甲氧西林金黄色葡萄球菌感染的发病密度为每10000次住院1.96例，2019年降至0.80例，达到监测期内的最低值。产碳青霉烯酶肠杆菌科细菌（CPE）引起的感染呈上升趋势，2014年为0.47，2019年为2.35。观察到的菌血症中耐亚胺培南鲍曼不动杆菌感染略有上升趋势（2012年为0.17,2019年为0.09）已得到纠正。未观察到耐万古霉素肠球菌感染病例。关于艰难梭菌感染，始于2012年的上升趋势已经巩固，在研究期末检测到的病例数增加了216%。

结论

目前检测到最相关的问题是CPE。这一时期分析的数据显示，所研究的多重耐药病原体的趋势有明显变化。这一事实今后必须得到证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d7/8638839/d75e1e7fba90/revespquimioter-34-483-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d7/8638839/49bf729a0960/revespquimioter-34-483-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d7/8638839/e1774aae8fdf/revespquimioter-34-483-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d7/8638839/5856c7ff227b/revespquimioter-34-483-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d7/8638839/b67f11b438a9/revespquimioter-34-483-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d7/8638839/d75e1e7fba90/revespquimioter-34-483-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d7/8638839/49bf729a0960/revespquimioter-34-483-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d7/8638839/e1774aae8fdf/revespquimioter-34-483-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d7/8638839/5856c7ff227b/revespquimioter-34-483-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d7/8638839/b67f11b438a9/revespquimioter-34-483-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d7/8638839/d75e1e7fba90/revespquimioter-34-483-g005.jpg

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