Cores-Calvo O, García-Sánchez E, Valero-Juan L F, García-Sánchez J E, García-García M I
Olaia Cores Calvo, Servicio de Microbiología y Parasitología. Complejo Asistencial Universitario de Salamanca. Paseo de San Vicente, 58-182, 37007, Salamanca.
Rev Esp Quimioter. 2016 Aug;29(4):206-13. Epub 2016 Jun 17.
To know the most relevant epidemiological features of Clostridium difficile infection (CDI) between 2005- 2014 in the province of Salamanca (Spain).
Descriptive cross-sectional study carried out through review of the clinical microbiologic records at Complejo Asistencial Universitario de Salamanca. Detection was performed according to standard methodology.
2.6% of stool samples analyzed for detection of C. difficile toxins (9,103) were positive. The average prevalence was 6.8 cases per 100,000 people per year. The mean age was 65 ± 21.4 years and the median 70 years. 59% of cases occurred in patients over 64 years, with an average prevalence of 16.5 (4 times higher than the 15-64 group). Most cases (86.4%) occurred in hospitalized patients, and the group of over 64 had the highest percentage of hospital CDI, with 55%.
A significant increase in the number of requests and in the prevalence of CDI over the decade studied is observed, and prevalence rates were significantly lower than those of other studies. The percentage of CDI increased significantly in both inpatient and community. Age and hospitaliza-tion were risk factors for developing CDI. After the introduc-ion of a molecular detection technique in 2014, the prevalence increased, being 2.5 times higher than 2013.
了解2005年至2014年西班牙萨拉曼卡省艰难梭菌感染（CDI）最相关的流行病学特征。
通过回顾萨拉曼卡大学综合医院的临床微生物学记录进行描述性横断面研究。按照标准方法进行检测。
检测艰难梭菌毒素的粪便样本（9103份）中，2.6%呈阳性。平均年患病率为每10万人6.8例。平均年龄为65±21.4岁，中位数为70岁。59%的病例发生在64岁以上患者中，平均患病率为16.5（是15 - 64岁组的4倍）。大多数病例（86.4%）发生在住院患者中，64岁以上组医院CDI的比例最高，为55%。
在所研究的十年间，CDI的检测请求数量和患病率显著增加，且患病率显著低于其他研究。住院患者和社区患者中CDI的比例均显著增加。年龄和住院是发生CDI的危险因素。2014年引入分子检测技术后，患病率增加，比2013年高出2.5倍。
