[Clinical characteristics of neuroendocrine carcinoma of nose and skull base and analysis of curative effect of endoscopic surgery].

To investigate the clinical features of neuroendocrine carcinoma of nose and skull base and the efficacy and prognosis of endoscopic resection. The clinical data of 7 patients with neuroendocrine carcinoma of nose and skull base treated by endoscopic surgery were retrospectively analyzed. According to the international TNM staging, there were 1 case of stage Ⅰ, 1 case of stage Ⅱ, 1 case of stage Ⅲ, 1 case of stage ⅣA and 3 cases of stage ⅣB. All patients were treated by endoscopic surgery, including 1 case of postoperative radiotherapy, 1 case of chemotherapy and 3 cases of radiotherapy and chemotherapy. During the follow-up of 9-58 months, 2 cases died after recurrence, 1 case had ipsilateral cervical lymph node metastasis（tumor-free survival after neck dissection）, and 4 cases had tumor-free survival at the last follow-up. At present, there is no standard treatment for neuroendocrine carcinoma of the nose and skull base. The comprehensive treatment based on complete resection of the tumor by endoscopic surgery is an effective and feasible treatment.