使用氟苯磺酰亚胺对 2-吲哚进行氟化。

Fluorination of 2-Indazoles Using -Fluorobenzenesulfonimide.

机构信息

Department of Chemistry, Visva-Bharati (A Central University), Santiniketan 731235, India.

出版信息

J Org Chem. 2021 Aug 6;86(15):10883-10888. doi: 10.1021/acs.joc.1c01253. Epub 2021 Jul 25.

DOI:10.1021/acs.joc.1c01253

Abstract

An efficient, simple, and metal-free fluorination of 2-indazoles has been developed using -fluorobenzenesulfonimide (NFSI) in water under ambient air. This transformation provides direct access to fluorinated indazole derivatives with broad functionalities in satisfactory yields. The experimental results suggest a radical mechanistic pathway of this protocol.

摘要

发展了一种在环境空气中、以 -氟代苯磺酰亚胺（NFSI）为氟源、在水中高效、简便、无需金属的 2-吲哚氟代反应。该转化方法以良好的收率为多种官能团的氟化吲哚衍生物提供了直接途径。实验结果表明该反应遵循自由基机理。