Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Gastroenterol Clin North Am. 2021 Sep;50(3):505-522. doi: 10.1016/j.gtc.2021.04.002.
The pathogenesis of irritable bowel syndrome is multifactorial and complex. Our understanding of its pathophysiology has evolved, but remains incompletely understood. Symptoms result from a dysregulation of brain-gut interactions. Evidence has identified alterations in central and peripheral (gut) mechanisms in irritable bowel syndrome and the bidirectional communication between the brain and the gut. Pertinent mechanisms include disturbed gut motility, visceral hypersensitivity, altered mucosal and immune function, altered gut microbiota, and altered central nervous system processing. This review addresses factors that increase the risk of irritable bowel syndrome and the central and peripheral mechanisms thought to underlie its symptoms.
肠易激综合征的发病机制是多因素和复杂的。我们对其病理生理学的理解已经发展，但仍不完全了解。症状是由于脑-肠相互作用的失调引起的。有证据表明，肠易激综合征的中枢和外周（肠道）机制以及大脑和肠道之间的双向通讯发生了改变。相关的机制包括肠道运动紊乱、内脏高敏性、粘膜和免疫功能改变、肠道微生物群改变以及中枢神经系统处理改变。这篇综述讨论了增加肠易激综合征风险的因素以及被认为是其症状基础的中枢和外周机制。
