宫颈癌患者血清CK17和CK19的表达及其预后价值。
The serum CK17 and CK19 expressions in cervical cancer patients and their prognostic value.
作者信息
He Xiangyi, Wang Yanyan, Ping Jinliang, Xu Wei, Fang Wei, Liu Jin
机构信息
Department of Pathology, Zhejiang North Medical Center (Huzhou Central Hospital) Huzhou 313003, Zhejiang Province, China.
出版信息
Am J Transl Res. 2021 Jun 15;13(6):6439-6445. eCollection 2021.
OBJECTIVE
This study was designed to quantify the serum CK17 and CK19 expressions in cervical cancer (CC) patients and determine their predictive value.
METHODS
A total of 124 CC patients admitted to Zhejiang North Medical Center (Huzhou Central Hospital) between November 2014 and November 2017 were recruited for the study and placed in a research group (the Res group), and 99 healthy individuals during the same period were also recruited for the study and placed in a control group (the Con group). Their serum CK17 and CK19 expressions were quantified, and the diagnostic significance of the two for CC was analyzed. Additionally, the patients were followed up for three years. The patients were then assigned to favorable and unfavorable prognosis groups, and then the predictive significance of CK17 and CK19 for such patients was evaluated.
RESULTS
The Res group presented significantly higher serum CK17 and CK19 expression levels than the Con group, and the two factors were positively associated. Additionally, neither of the AUCs for serum CK17 and CK19 in identifying CC were less than 0.800, and the AUC of the combination of the two in identifying it was not smaller than 0.900. The AUC of the combination of serum CK17 and CK19 in identifying unfavorable CC prognoses was approximate 0.850, and high expression levels CK17 and CK19 were closely related with low three-year overall survival rates.
CONCLUSION
Serum CK17 combined with serum CK19 is of great diagnostic and predictive significance for CC.
目的
本研究旨在量化宫颈癌（CC）患者血清中CK17和CK19的表达水平，并确定其预测价值。
方法
选取2014年11月至2017年11月在浙江北部医疗中心（湖州市中心医院）收治的124例CC患者作为研究组（Res组），同期选取99例健康个体作为对照组（Con组）。对两组血清中CK17和CK19的表达水平进行量化，并分析二者对CC的诊断意义。此外，对患者进行三年随访。然后将患者分为预后良好组和预后不良组，评估CK17和CK19对这类患者的预测意义。
结果
Res组血清中CK17和CK19的表达水平显著高于Con组，且二者呈正相关。此外，血清CK17和CK19鉴别CC的AUC均不小于0.800，二者联合鉴别CC的AUC不小于0.900。血清CK17和CK19联合鉴别CC不良预后的AUC约为0.850，且CK17和CK19高表达与三年总生存率低密切相关。
结论
血清CK17联合血清CK19对CC具有重要的诊断和预测意义。
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