蒙脱石散联合地塞米松治疗急性放射性肠炎的疗效
Curative effects of montmorillonite powder combined with dexamethasone on acute radiation enteritis.
作者信息
Chen Wenping, Ma Qiaoling, Yang Limin, Zhang Lei, Zhu Jiandong, Lin Wanlin
机构信息
Department of Pelvic Anorectal Surgery, Xi'an Daxing Hospital Xi'an, Shaanxi Province, China.
出版信息
Am J Transl Res. 2021 Jun 15;13(6):7270-7275. eCollection 2021.
OBJECTIVE
To investigate the curative effects of montmorillonite powder combined with dexamethasone on acute radiation enteritis.
METHODS
Eighty-six patients with acute radiation enteritis were enrolled in this prospective research, and they were divided into a control group and an intervention group using a random number table, with 43 cases in each group. Patients in both groups received conventional treatment. The control group was treated with montmorillonite powder, and the intervention group was treated with retention enema with dexamethasone based on montmorillonite powder. The grades of mucosal damage, changes in cytokine levels, the efficacy of colonoscopy, and overall curative effects of the two groups before and after treatment were observed.
RESULTS
After treatment, the levels of IL-2 and IFN-γ of the two groups were significantly reduced, and the level of IL-10 was significantly increased. The intervention group was significantly better than the control group (all P<0.001). The grades of mucosal damage in the intervention group showed better improvement than that in the control group (P<0.01), and the overall curative effects in the intervention group were significantly better than those in the control group (both P<0.05).
CONCLUSION
Montmorillonite powder combined with dexamethasone is effective in treating patients with acute radiation enteritis, which can effectively alleviate mucosal damage, improve inflammation, and promote patient recovery. It has the value of promotion and application.
目的
探讨蒙脱石散联合地塞米松治疗急性放射性肠炎的疗效。
方法
86例急性放射性肠炎患者纳入本前瞻性研究，采用随机数字表法分为对照组和干预组，每组43例。两组患者均接受常规治疗。对照组给予蒙脱石散治疗，干预组在蒙脱石散基础上给予地塞米松保留灌肠。观察两组治疗前后黏膜损伤程度、细胞因子水平变化、结肠镜检查疗效及总体疗效。
结果
治疗后，两组IL-2和IFN-γ水平显著降低，IL-10水平显著升高。干预组明显优于对照组（均P<0.001）。干预组黏膜损伤程度改善优于对照组（P<0.01），干预组总体疗效明显优于对照组（均P<0.05）。
结论
蒙脱石散联合地塞米松治疗急性放射性肠炎患者疗效显著，可有效减轻黏膜损伤，改善炎症，促进患者康复。具有推广应用价值。
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