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急性面瘫患者对侧面部注射肉毒杆菌毒素可能改善功能恢复:现状与未来方向

Contralateral Facial Botulinum Toxin Injection in Cases with Acute Facial Paralysis May Improve the Functional Recovery: Where We Stand and the Future Direction.

作者信息

Hamidian Jahromi Alireza, Konofaos Petros

机构信息

Department of Plastic and Reconstructive Surgery, Rush University Medical Center, Chicago, Illinois, USA.

Department of Plastic Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

出版信息

World J Plast Surg. 2021 May;10(2):89-92. doi: 10.29252/wjps.10.2.89.

DOI:10.29252/wjps.10.2.89
PMID:34307103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8290456/
Abstract

Facial nerve (FN) impacts the function of the facial musculature by creating muscle tone at rest as well as the muscles' voluntary and involuntary contractions. Temporary or permanent loss of FN function could be due to different etiologic factors. Acute facial paralysis (FP) could be significantly stressful for the patient and the family and apart from supportive measures management options are quite restricted. While botulinum toxin (BTX) injection in the FP setting has been used mostly to address the compensatory hyperkinesia in the non-paralyzed side of the face, there are evidence to suggest contralateral injection of the non-paralyzed face with BTX may improve/enhance the recovery time of the FP in cases where the FP has a reversible cause. While further studies are underway, using the current evidence as discussed could potentially justify the current usage of contralateral BTX injection and biofeedback exercises in the setting of the temporary FP specialty due to lack of effective alternative management options.

摘要

面神经(FN)通过在静息状态下产生肌张力以及肌肉的自主和非自主收缩来影响面部肌肉组织的功能。FN功能的暂时或永久性丧失可能归因于不同的病因。急性面瘫(FP)对患者及其家人来说可能会造成极大的压力,除了支持性措施外,治疗选择非常有限。虽然肉毒杆菌毒素(BTX)注射在FP治疗中主要用于解决面部未瘫痪侧的代偿性运动亢进,但有证据表明,在FP有可逆病因的情况下,对未瘫痪侧面部进行BTX对侧注射可能会改善/缩短FP的恢复时间。虽然进一步的研究正在进行中,但由于缺乏有效的替代治疗选择,根据所讨论的现有证据,在临时FP专科治疗中使用对侧BTX注射和生物反馈训练可能是合理的。

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本文引用的文献

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Plast Reconstr Surg. 2019 Dec;144(6):1112e-1113e. doi: 10.1097/PRS.0000000000006215.
2
Contralateral Botulinum Toxin Improved Functional Recovery after Tibial Nerve Repair in Rats.双侧肉毒毒素改善大鼠修复胫神经后功能恢复
Plast Reconstr Surg. 2018 Dec;142(6):1511-1519. doi: 10.1097/PRS.0000000000004981.
3
Contralateral botulinum injections in patients with residual facial asymmetry and contralateral hyperkinesis after primary facial palsy surgery.原发性面瘫手术后存在面部残余不对称和对侧运动亢进患者的对侧肉毒杆菌注射。
Ann Ital Chir. 2015 May-Jun;86(3):201-6.
4
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J Plast Reconstr Aesthet Surg. 2015 Jan;68(1):71-8. doi: 10.1016/j.bjps.2014.08.067. Epub 2014 Sep 18.
5
Botulinum toxin injection of both sides of the face to treat post-paralytic facial synkinesis.面部两侧注射肉毒毒素治疗面瘫后面部联动。
J Plast Reconstr Aesthet Surg. 2013 Aug;66(8):1058-63. doi: 10.1016/j.bjps.2013.04.012. Epub 2013 May 15.
6
Contralateral botulinum toxin injection to improve facial asymmetry after acute facial paralysis.急性面瘫后面部不对称的对侧肉毒毒素注射治疗。
Otol Neurotol. 2013 Feb;34(2):319-24. doi: 10.1097/mao.0b013e31827c9f58.
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Eye (Lond). 2012 Nov;26(11):1431-6. doi: 10.1038/eye.2012.189. Epub 2012 Sep 14.
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Neurorehabil Neural Repair. 2011 Jan;25(1):15-23. doi: 10.1177/1545968310376058. Epub 2010 Oct 7.
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Plast Reconstr Surg. 2007 Sep 15;120(4):917-927. doi: 10.1097/01.prs.0000244311.72941.9a.
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