Thirunavukkarasu Balamurugan, Samanta Jayanta, Bhatia Prateek, Bal Amanjit
Post Graduate Institute of Medical Education & Research, Departments of Histopathology, Chandigarh, India.
Post Graduate Institute of Medical Education & Research, Department of Gastroenterology, Chandigarh, India.
Autops Case Rep. 2021 May 6;11:e2021278. doi: 10.4322/acr.2021.278. eCollection 2021.
Peritoneal lymphomatosis (PL) is a rare presentation of extranodal precursor leukemia/lymphoma. The presentation is often non-specific, leading to delayed diagnosis and treatment. In this case, though the preliminary diagnosis was established on ascitic fluid cytology, the disease progressed rapidly, leading to demise before initiating chemotherapy. Immunophenotyping and molecular studies, performed later, established a diagnosis of de novo B-cell precursor leukemia/lymphoma with , rearrangements (Double-hit lymphoma). , rearrangements are rarely reported in precursor B-lymphoma/leukemia which carry dismal prognosis. In this report, we illustrate autopsy findings of PL in an elderly gentleman who presented with ascites for evaluation.
腹膜淋巴瘤（PL）是结外前驱性白血病/淋巴瘤的一种罕见表现形式。其临床表现通常不具有特异性，导致诊断和治疗延迟。在本病例中，尽管通过腹水细胞学检查初步确诊，但疾病进展迅速，在开始化疗前就导致了患者死亡。随后进行的免疫表型分析和分子研究确诊为伴有 、 重排的原发性B细胞前驱性白血病/淋巴瘤（双打击淋巴瘤）。 、 重排在预后极差的前驱性B淋巴瘤/白血病中鲜有报道。在本报告中，我们阐述了一位因腹水前来评估的老年男性患者腹膜淋巴瘤的尸检结果。
