Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamilnadu, India.
Department of Basic Sciences and Humanities, Rajiv Gandhi Institute of Petroleum Technology, An Institution of National Importance, Jais, Amethi-229304, Uttar Pradesh, India.
Dalton Trans. 2021 Aug 4;50(30):10369-10373. doi: 10.1039/d1dt01604k.
To avoid the side effects of the current popular platinum-based anticancer drugs, researchers have made tireless attempts to design appropriate GSH-resistant Ru(ii)-arene complexes. In this regard, luminescent ruthenium(ii)-p-cymene-imidazophenanthroline complexes were developed as promising highly cytoselective cancer theraputic agents for HeLa and Caco-2 cells.
为避免当前流行的基于铂的抗癌药物的副作用，研究人员不懈尝试设计合适的 GSH 抗性 Ru(ii)-芳环配合物。在这方面，开发了发光的 Ru(ii)-p-枯茗-咪唑菲咯啉配合物作为有前途的高细胞选择性癌症治疗剂，用于 HeLa 和 Caco-2 细胞。
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