半夹心 Ru(II)--蒎烯亚硝酸盐配合物选择性诱导顺铂耐药恶性黑素瘤细胞死亡。
A half sandwich Ru(II)--cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells.
机构信息
Department of Medicinal and Applied Chemistry, Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
出版信息
Dalton Trans. 2024 Jul 30;53(30):12620-12626. doi: 10.1039/d4dt01012d.
The Ru(II)-nitrite complex, Ru4, is explored to release nitric oxide (NO) under acidic conditions and selectively induce a cytotoxic effect towards SK-MEL-28 cisplatin-resistant malignant melanoma cells. These findings suggest that targeting the tumor-associated pHe level could be an effective strategy for the drug function of Ru(II)-nitrite compounds.
研究了 Ru(II)-亚硝酸盐配合物 Ru4 在酸性条件下释放一氧化氮 (NO) 的能力，并选择性地诱导 SK-MEL-28 顺铂耐药恶性黑素瘤细胞产生细胞毒性作用。这些发现表明，针对肿瘤相关的 pHe 水平可能是 Ru(II)-亚硝酸盐化合物发挥药物作用的有效策略。
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