细胞因子基因多态性与糖尿病肾病的关系：一项全面的系统评价和荟萃分析。
Association between polymorphisms of cytokine genes and diabetic nephropathy: A comprehensive systematic review and meta-analysis.
机构信息
Endocrinology Department, the Second People's Hospital of Yibin, Yibin, China.
出版信息
Int J Clin Pract. 2021 Nov;75(11):e14634. doi: 10.1111/ijcp.14634. Epub 2021 Aug 8.
AIM
Diabetic nephropathy (DN) is one of the microvascular complications of diabetes, leading to renal failure. In this study, we sought to systematically investigate the cytokine gene polymorphisms association with DN.
METHODS
A structured bibliographic search on PubMed, Scopus, and EMBASE databases has been performed to identify related papers. The odds ratio and corresponding 95% confidence intervals (CIs) were calculated to estimate the association.
RESULTS
Overall, the pooled results showed that the dominant models of TNF-α rs1800629, IL-1β rs16944, IL-8 rs4073, and IL-10 rs1800896 were associated with increased susceptibility to DN. Also, the pooled analyses of the mutant allele vs wild allele of TNF-α rs1800629, rs1799964, IL-1β rs16944, and IL-8 rs4073 were associated with increased susceptibility to DN. Rs1800629, rs16944, rs4073, and rs1800896 polymorphisms were significantly associated with DN susceptibility, suggesting its potential use as a genetic risk marker in the population.
目的
糖尿病肾病（DN）是糖尿病的微血管并发症之一，可导致肾衰竭。本研究旨在系统研究细胞因子基因多态性与 DN 的关系。
方法
对 PubMed、Scopus 和 EMBASE 数据库进行了结构化文献检索，以确定相关文献。采用比值比（OR）及其 95%置信区间（CI）来评估相关性。
结果
总体而言，汇总结果显示 TNF-α rs1800629、IL-1β rs16944、IL-8 rs4073 和 IL-10 rs1800896 的优势模型与 DN 的易感性增加相关。此外，TNF-α rs1800629、rs1799964、IL-1β rs16944 和 IL-8 rs4073 的突变等位基因与野生等位基因的汇总分析也与 DN 的易感性增加相关。rs1800629、rs16944、rs4073 和 rs1800896 多态性与 DN 的易感性显著相关，提示其可能作为人群中的遗传风险标志物。
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