Reiz S, Nath S, Pontén E
Acta Anaesthesiol Scand. 1979 Feb;23(1):93-6. doi: 10.1111/j.1399-6576.1979.tb01426.x.
The hemodynamic effects of prenalterol, a new beta1-adrenoreceptor agonist, on hypotension induced by a thoracic epidural block extending between T1 and T12 and thereby blocking the cardiac sympathetic supply have been studied in eight patients scheduled for abdominal aortic aneurysm resection. The thoracic epidural block induced a drop in blood pressure, due to a reduction in cardiac output and systemic vascular resistance. Intravenous infusion of 10 mg of prenalterol rapidly and effectively reversed the hypotension by an increase in cardiac output without any effects on systemic vascular resistance or heart rate. The results indicate that prenalterol is a pure beta1 agonist with a marked inotropic but no chronotropic property.
对8例计划行腹主动脉瘤切除术的患者，研究了新型β1 - 肾上腺素能受体激动剂普瑞特罗对T1至T12节段胸段硬膜外阻滞所致低血压的血流动力学影响，该阻滞会阻断心脏交感神经供应。胸段硬膜外阻滞导致血压下降，原因是心输出量和全身血管阻力降低。静脉输注10 mg普瑞特罗可通过增加心输出量迅速有效地逆转低血压，而对全身血管阻力或心率无任何影响。结果表明，普瑞特罗是一种纯β1激动剂，具有显著的正性肌力作用但无变时性作用。
