IRCCS - Fondazione Bietti, Rome, Italy.
Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Via Olgettina, 60, Milan, Italy.
Sci Rep. 2021 Jul 26;11(1):15183. doi: 10.1038/s41598-021-94580-z.
To study the outer retina morpho-functional characteristics and the choriocapillaris (CC) features in type 1 diabetic (T1D) patients, with and without signs of diabetic retinopathy (NPDR and NoDR). Twenty-five NPDR and 18 NoDR eyes were imaged by Optical Coherence Tomography Angiography. Ellipsoid zone (EZ) "normalized" reflectivity and CC perfusion density parameters, as flow deficits number (FDn), flow deficit average area (FDa) and flow deficit percentage (FD%), were analysed. Multifocal electroretinogram (mfERG) response amplitude densities (RADs) were measured. Mean EZ "normalized" reflectivity, CC FDn and FD% values, were similar (p > 0.05) in both groups, FDa was significant greater (p > 0.05) in NPDR compared with NoDR eyes. MfERG-RADs were similar in both groups. NPDR eyes showed a significant (p < 0.05) linear correlation between RADs and both, CC FDa and FD%. The EZ "normalized" reflectivity was negatively correlated with CC FD% in NoDR eyes. In NPDR T1D eyes a significant relationship between abnormal outer retina functional responses and CC impairment was observed, while in NoDR eyes the photoreceptor reflectivity was correlated to CC abnormalities. The outer retina dysfunction in NPDR correlated to CC drop-out let hypothesize that the outer retinal elements are functionally impaired in proportion to the CC vascular supply deficit.
为了研究 1 型糖尿病（T1D）患者有无糖尿病视网膜病变（NPDR 和 NoDR）迹象的外视网膜形态功能特征和脉络膜毛细血管（CC）特征，对 25 只 NPDR 眼和 18 只 NoDR 眼进行了光相干断层扫描血管造影。分析了椭圆体带（EZ）“归一化”反射率和 CC 灌注密度参数，如血流不足数（FDn）、血流不足平均面积（FDa）和血流不足百分比（FD%）。还测量了多焦视网膜电图（mfERG）的反应幅度密度（RAD）。两组的平均 EZ“归一化”反射率、CC Fdn 和 FD%值相似（p>0.05），NPDR 组的 FDa 明显大于 NoDR 组（p>0.05）。两组的 mfERG-RAD 相似。NPDR 眼的 RAD 与 CC FDa 和 FD%之间呈显著的线性相关性（p<0.05）。NoDR 眼的 EZ“归一化”反射率与 CC FD%呈负相关。在 NPDR T1D 眼中，观察到外视网膜功能异常与 CC 损伤之间存在显著的关系，而在 NoDR 眼中，光感受器的反射率与 CC 异常相关。NPDR 中的外视网膜功能障碍与 CC 缺失相关，这表明外视网膜元素的功能受损与 CC 血管供应不足成比例。
