Bauer P, Stützer H, Vierzig A
Institut für Medizinische Dokumentation und Statistik, Universität zu Köln.
Langenbecks Arch Chir. 1987;372:603-6. doi: 10.1007/BF01297890.
The problem of making valid statements about the prognosis of survival after radical operation of stomach cancer, based on retrospective or prospective studies, is investigated. Some explanations are given for contradictory or non-reproducible results in different subgroups. Especially the problem of searching for "significant" results by multiple testing of different subgroups (data snooping) is treated critically. In case of remaining open questions randomised studies appear to be inevitable.
本文探讨了基于回顾性或前瞻性研究对胃癌根治术后生存预后做出有效陈述的问题。针对不同亚组中相互矛盾或不可重复的结果给出了一些解释。尤其对通过对不同亚组进行多次检验（数据窥探）来寻找“显著”结果的问题进行了批判性探讨。在仍存在未解决问题的情况下，随机对照研究似乎是不可避免的。
