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CD70-targeting CAR-T cells have potential activity against CD19-negative B-cell Lymphoma.

作者信息

Deng Wenhai, Chen Panpan, Lei Wen, Xu Yang, Xu Nengwen, Pu Jeffrey J, Liang Aibin, Qian Wenbin

机构信息

Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, P. R. China.

Department of Hematology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, P. R. China.

出版信息

Cancer Commun (Lond). 2021 Sep;41(9):925-929. doi: 10.1002/cac2.12201. Epub 2021 Jul 27.

DOI:10.1002/cac2.12201
PMID:34313014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8441055/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3400/8441055/4d3ad26c1ba9/CAC2-41-925-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3400/8441055/4d3ad26c1ba9/CAC2-41-925-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3400/8441055/4d3ad26c1ba9/CAC2-41-925-g001.jpg

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Blood. 2021 Jul 29;138(4):318-330. doi: 10.1182/blood.2020008221.
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Theranostics. 2020 Jun 18;10(17):7622-7634. doi: 10.7150/thno.43991. eCollection 2020.
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Optimized tandem CD19/CD20 CAR-engineered T cells in refractory/relapsed B-cell lymphoma.
CD70:癌症综合诊断与治疗的新兴靶点。
Clin Transl Med. 2025 Jul;15(7):e70400. doi: 10.1002/ctm2.70400.
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T cell-redirecting therapies in hematological malignancies: Current developments and novel strategies for improved targeting.血液系统恶性肿瘤中的 T 细胞重定向疗法:为改善靶向性而开发的新策略和新进展。
Mol Ther. 2024 Sep 4;32(9):2856-2891. doi: 10.1016/j.ymthe.2024.07.028. Epub 2024 Aug 5.
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CAR-based immunotherapy for breast cancer: peculiarities, ongoing investigations, and future strategies.基于嵌合抗原受体(CAR)的乳腺癌免疫疗法:特点、正在进行的研究及未来策略。
Front Immunol. 2024 Apr 12;15:1385571. doi: 10.3389/fimmu.2024.1385571. eCollection 2024.
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The development of chimeric antigen receptor T-cells against CD70 for renal cell carcinoma treatment.嵌合抗原受体 T 细胞针对肾细胞癌治疗的 CD70 的开发。
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