Qing Yu-Feng, Zhang Quan-Bo, Dai Fei, Huang Yu-Qin, Zheng Jian-Xiong, Tang Yi-Ping, Dong Zeng-Rong, Wang Shun-Bing
Research Center of Hyperuricemia and Gout, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Curr Rheumatol Rev. 2021;17(4):373-378. doi: 10.2174/1573397117666210726125632.
Previous studies demonstrated that MicroRNA-146a (miR-146a) plays an important role in the regulation of autoinflammatory diseases including primary gout. The G/C polymorphism (rs2910164) in the precursor sequence of miR-146a caused its stem region to change from G: U to C: U,which can contribute to the susceptibility of human diseases. However, no genetic relevance studies of miR-146a gene polymorphisms to gout have been reported by now.
The purpose of this study was to analyze the association between the miR-146a rs2910164 genetic polymorphism and the susceptibility of the Chinese Han population to primary gout.
1130 Chinese Han participants (including 606 primary gout patients and 524 gender and age-matched healthy control subjects) were recruited and the 5'exonuclease TaqMan® technology was used to perform miR-146a rs2910164 genotyping.
After statistical analysis, no significant differences were observed between gout patients and healthy controls in genotype and allele frequency.
Our results indicate that there is no evidence for the involvement of the miR-146a rs2910164 polymorphisms in susceptibility to primary gout in the Chinese Han population.
先前的研究表明，微小RNA-146a（miR-146a）在包括原发性痛风在内的自身炎症性疾病的调节中起重要作用。miR-146a前体序列中的G/C多态性（rs2910164）导致其茎区从G:U变为C:U，这可能导致人类疾病易感性增加。然而，目前尚无关于miR-146a基因多态性与痛风的遗传相关性研究报道。
本研究旨在分析miR-146a rs2910164基因多态性与中国汉族人群原发性痛风易感性之间的关联。
招募1130名中国汉族参与者（包括606例原发性痛风患者和524例性别和年龄匹配的健康对照者），采用5'核酸外切酶TaqMan®技术对miR-146a rs2910164进行基因分型。
经过统计学分析，痛风患者与健康对照者在基因型和等位基因频率上无显著差异。
我们的结果表明，没有证据表明miR-146a rs2910164多态性参与中国汉族人群原发性痛风的易感性发生。
