经肛门超声引导下肉毒毒素治疗慢性肛裂的疗效和安全性。

Efficacy and Safety of Endoanal Ultrasound-Guided Botulinum Toxin in Chronic Anal Fissure.

机构信息

Department of General Surgery, Ordu Training and Research Hospital, Ordu, Turkey.

Department of General Surgery, Ankara University School of Medicine, Istanbul, Turkey.

出版信息

Am Surg. 2023 May;89(5):2125-2128. doi: 10.1177/00031348211034750. Epub 2021 Jul 27.

DOI:10.1177/00031348211034750

PMID:34313489

Abstract

We aimed to evaluate the efficacy and safety of endoanal ultrasound (EAUS)-guided botulinum toxin (BT) in the treatment of chronic anal fissure (CAF). All patients were classified into 2 groups: conventional and EAUS groups. In total, 90 units of BT were injected into the internal anal sphincter at the 3, 6, and 9 o'clock positions in the EAUS group. An injection was performed into the intersphincteric space at the 3, 6, and 9 o'clock positions in the conventional group. Adverse effects and efficacy were analyzed. There were 44 patients: 26 in the conventional group and 18 in the EAUS group. Pain and incontinence rates were similar between groups ( > .05). The efficacy rate was higher in the EAUS group (69.23%) than in the conventional group (81.82%), but this difference was not significant ( = .466). EAUS-guided BT injection is safe and effective in patients with CAFs.

摘要

我们旨在评估经肛门超声（EAUS）引导下肉毒毒素（BT）治疗慢性肛裂（CAF）的疗效和安全性。所有患者分为 2 组：常规组和 EAUS 组。EAUS 组在 3、6、9 点钟位置将 90 个单位的 BT 注入内括约肌，常规组在 3、6、9 点钟位置将注射针注入括约肌间间隙。分析不良反应和疗效。共有 44 例患者：常规组 26 例，EAUS 组 18 例。两组间疼痛和失禁发生率相似（>.05）。EAUS 组的疗效（69.23%）高于常规组（81.82%），但差异无统计学意义（=.466）。EAUS 引导下 BT 注射治疗 CAF 安全有效。