State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xueyuan Road, Haidian District, Beijing 100191, China.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xueyuan Road, Haidian District, Beijing 100191, China.
Fitoterapia. 2021 Sep;153:104998. doi: 10.1016/j.fitote.2021.104998. Epub 2021 Jul 24.
Three new flavonoids, ephedroside A (1), ephedroside B (2), ephedroside C (3), together with fifty-four known compounds 4-57 were isolated from the EtOH extract of the herbaceous stems of Ephedra sinica. The structures of these compounds were elucidated by spectroscopic techniques, as well as by comparison with literature data. Thirty-eight of these compounds were isolated from the genus Ephedra for the first time. The antimicrobial activities of eight compounds were tested by measuring the minimum inhibitory concentrations (MIC) against bacteria (both Gram positive and Gram negative) and fungi, and were found to be in the range of 0.105-0.926 mM. Among them, compound 2 showed the best antimicrobial activity against Pseudomonas aeruginosa with MIC value of 0.105 mM.
从中国麻黄的草本茎乙醇提取物中分离得到三种新的黄酮类化合物，麻黄苷 A（1）、麻黄苷 B（2）和麻黄苷 C（3），以及 54 种已知化合物 4-57。这些化合物的结构通过光谱技术以及与文献数据的比较来阐明。其中 38 种化合物是首次从麻黄属中分离得到的。通过测定最小抑菌浓度（MIC）来测试八种化合物对细菌（革兰氏阳性和革兰氏阴性）和真菌的抗菌活性，结果表明其范围在 0.105-0.926 mM 之间。其中，化合物 2 对铜绿假单胞菌的抗菌活性最好，MIC 值为 0.105 mM。
