吸入二甲苯对大鼠颅内自我刺激行为的影响。

Effect of inhalation of xylene on intracranial self-stimulation behavior in rat.

作者信息

Wimolwattanapun S, Ghosh T K, Mookherjee S, Copeland R L, Pradhan S N

机构信息

Department of Pharmacology, Howard University College of Medicine, Washington, D.C. 20059.

出版信息

Neuropharmacology. 1987 Nov;26(11):1629-32. doi: 10.1016/0028-3908(87)90013-x.

DOI:10.1016/0028-3908(87)90013-x

PMID:3431665

Abstract

The effect of the inhalation of xylene on intracranial self-stimulation behavior was studied in rats in a flow-through (dynamic) inhalational behavioral chamber. Rats were exposed successively to four graded concentrations (102, 192, 419 and 623 ppm) of xylene vapor during 2-hr sessions on different days. The rate of lever-pressing showed a dose-dependent decrease during exposure to 192, 419 and 623 ppm of xylene. The 4-hr exposure to the smallest concentration (106 ppm) of xylene failed to show any effect on self-stimulation behavior. During a 5-day 2 hr/day exposure, the decrease in response observed on the 1st day was further accentuated with a nadir on the 3rd day; from the 4th day onwards, the depressant effect was attenuated showing the development of tolerance.

摘要

在一个流通式（动态）吸入行为实验箱中，研究了大鼠吸入二甲苯对其颅内自我刺激行为的影响。在不同的日子里，大鼠在2小时的实验时段内依次暴露于四种分级浓度（102、192、419和623 ppm）的二甲苯蒸气中。在暴露于192、419和623 ppm二甲苯期间，压杆速率呈剂量依赖性下降。暴露于最低浓度（106 ppm）的二甲苯4小时，未对自我刺激行为产生任何影响。在每天2小时、持续5天的暴露过程中，第1天观察到的反应下降在第3天进一步加剧，出现最低点；从第4天起，抑制作用减弱，表明产生了耐受性。