Association between ozone exposure and prevalence of mumps: a time-series study in a Megacity of Southwest China.

In the present study, we aim to evaluate the delayed and cumulative effect of ozone (O) exposure on mumps in a megacity with high population density and high humidity. We took Chongqing, a megacity in Southwest China, as the research area and 2013-2017 as the research period. A total of 49,258 confirmed mumps cases were collected from 122 hospitals of Chongqing. We employed the distributed lag nonlinear models with quasi-Poisson link to investigate the relationship between prevalence of mumps and O exposure after adjusting for the effects of meteorological conditions. The results show that the effect of O exposure on mumps was mainly manifested in the lag of 0-7 days. The single-day ;lag effect was the most obvious on the 4th day, with the relative risk (RR) of mumps occurs of 1.006 (95% CI: 1.003-1.007) per 10 μg/m in the O exposure. The cumulative RR within 7 days was 1.025 (95% CI: 1.013-1.038). Our results suggest that O exposure can increase the risk of mumps infection, which fills the gap of relevant research in mountainous areas with high population density and high humidity.