Li Xiaohua, Zhang Guoxing, Cao Xia
Department of Infectious Diseases, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Department of Pharmacology, School of Pharmacy, Jilin University, Fujin Road, Changchun, 130021, Jilin, China.
Cardiovasc Drugs Ther. 2023 Feb;37(1):199-216. doi: 10.1007/s10557-021-07229-4. Epub 2021 Jul 28.
In addition to the key role in hemostasis and thrombosis, platelets have also been wildly acknowledged as immune regulatory cells and involving in the pathogenesis of inflammation-related diseases. Since purine receptor P2Y12 plays a crucial role in platelet activation, P2Y12 antagonists such as clopidogrel, prasugrel, and ticagrelor have been widely used in cardiovascular diseases worldwide in recent decades due to their potent antiplatelet and antithrombotic effects. Meanwhile, the role of P2Y12 in inflammatory diseases has also been extensively studied. Relatively, there are few studies on the regulation of P2Y12. This review first summarizes the various roles of P2Y12 in the process of platelet activation, as well as downstream effects and signaling pathways; then introduces the effects of P2Y12 in inflammatory diseases such as sepsis, atherosclerosis, cancer, autoimmune diseases, and asthma; and finally reviews the current researches on P2Y12 regulation.
除了在止血和血栓形成中发挥关键作用外，血小板也已被广泛认可为免疫调节细胞，并参与炎症相关疾病的发病机制。由于嘌呤受体P2Y12在血小板激活中起关键作用，近几十年来，氯吡格雷、普拉格雷和替格瑞洛等P2Y12拮抗剂因其强大的抗血小板和抗血栓作用而在全球范围内广泛用于心血管疾病。同时，P2Y12在炎症性疾病中的作用也得到了广泛研究。相对而言，关于P2Y12调节的研究较少。本综述首先总结了P2Y12在血小板激活过程中的各种作用，以及下游效应和信号通路；然后介绍了P2Y12在脓毒症、动脉粥样硬化、癌症、自身免疫性疾病和哮喘等炎症性疾病中的作用；最后综述了目前关于P2Y12调节的研究。
