分析 CFP1 突变景观对表观遗传信号的影响。
Analyzing the impact of CFP1 mutational landscape on epigenetic signaling.
机构信息
Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.
Shanghai Institute of Materia Medica-University of Ottawa Research Center in Systems and Personalized Pharmacology, University of Ottawa, Ottawa, ON, Canada.
出版信息
FASEB J. 2021 Aug;35(8):e21790. doi: 10.1096/fj.202100427R.
CXXC Zinc finger protein 1 (CFP1) is a multitasking protein playing essential roles during various developmental processes. Its ability to interact with several proteins contribute to several epigenetic events. Here, we review CFP1's functions and its impact on DNA methylation and the post-translational modification of histone proteins such as lysine acetylation and methylation. We will also discuss the potential role of CFP1 in carcinogenesis and the impact of the mutations identified in patients suffering from various cancers.
CXXC 锌指蛋白 1（CFP1）是一种多功能蛋白，在多种发育过程中发挥着重要作用。它与多种蛋白质相互作用的能力促成了几种表观遗传事件。在这里，我们回顾了 CFP1 的功能及其对 DNA 甲基化和组蛋白蛋白（如赖氨酸乙酰化和甲基化）的翻译后修饰的影响。我们还将讨论 CFP1 在癌症发生中的潜在作用以及在患有各种癌症的患者中发现的突变的影响。
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