Hsu Wen-Tung, Yang Deng-Ho, Liao Chun-Cheng, Chen Jia-Wen, Hsu Wen-Hsiu, Kuo Chia-Wen, Hsu Hung-Chang, Chang Sheng-Huang, Chen Li-Mien
Division of Laboratory, Taichung Armed Force General Hospital, Taichung, Taiwan, Republic of China.
Department of Internal Medicine, Taichung Armed Force General Hospital, Taichung, Taiwan, Republic of China.
Diabetes Metab Syndr Obes. 2021 Jul 20;14:3337-3344. doi: 10.2147/DMSO.S303252. eCollection 2021.
To evaluate the blood glucose and renal function, determine the prevalence of hyperglycemia/diabetes mellitus (DM) and renal disease (nephropathy), and investigate the association between hyperglycemia/DM and renal disease in patients with viral hepatitis (VH).
A total of 491 subjects were included in the study. Patients with VH were further divided into the hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, and HBV-HCV co-infection subgroups. Fasting blood glucose, glycated hemoglobin (HbA1c), glycated albumin (GA), glutamic oxaloacetic transaminase (GOT), creatinine (Cr), and cystatin C (Cys C) levels were measured. Urine microalbumin levels were also assessed. Formulas for estimated average glucose calculated using glycated albumin(eAG(GA)), estimated average glucose calculated using HbA1c (eAG(HbA1c)), and estimated glomerular filtration rate calculated using cystatin C (eGFRcys) were used to evaluate the average glucose and renal function.
The prevalence of hyperglycemia/DM and renal disease was significantly higher in the VH group, especially in the HCV subgroup. The prevalence of renal disease was significantly higher in patients with VH with eAG(GA) ≥200 mg/dL.
Our study used multiple parameters to evaluate blood glucose and renal function in patients with VH and found that hyperglycemia/DM and renal disease are closely associated with VH, especially in subjects with HCV infection. Patients with VH, especially those with HCV infection and hyperglycemia/DM, were particularly vulnerable to renal disease.
评估血糖和肾功能，确定病毒性肝炎（VH）患者中高血糖/糖尿病（DM）和肾脏疾病（肾病）的患病率，并研究高血糖/DM与肾脏疾病之间的关联。
本研究共纳入491名受试者。VH患者进一步分为乙型肝炎病毒（HBV）感染、丙型肝炎病毒（HCV）感染和HBV-HCV合并感染亚组。测量空腹血糖、糖化血红蛋白（HbA1c）、糖化白蛋白（GA）、谷草转氨酶（GOT）、肌酐（Cr）和胱抑素C（Cys C）水平。还评估尿微量白蛋白水平。使用基于糖化白蛋白计算的估计平均血糖（eAG(GA)）、基于HbA1c计算的估计平均血糖（eAG(HbA1c)）以及基于胱抑素C计算的估计肾小球滤过率（eGFRcys）公式来评估平均血糖和肾功能。
VH组中高血糖/DM和肾脏疾病的患病率显著更高，尤其是在HCV亚组中。eAG(GA)≥200 mg/dL的VH患者中肾病患病率显著更高。
我们的研究使用多个参数评估VH患者的血糖和肾功能，发现高血糖/DM和肾脏疾病与VH密切相关，尤其是在HCV感染患者中。VH患者，尤其是那些合并HCV感染和高血糖/DM的患者，特别容易患肾脏疾病。
