2019年至2020年期间，对在军队医院接受血管造影的吸烟患者的肺活量测定结果与冠状动脉疾病严重程度进行评估。

Evaluation of spirometry findings with severity of coronary artery disease in smoker patients undergoing angiography in military hospital during 2019-2020.

作者信息

Samani Milad Kabiri, Mosavi Seyed Hossein, Arefizadeh Reza

机构信息

School of Medicine, Aja University of Medical Sciences Tehran, Iran.

Department of Cardiology, School of Medicine, Aja University of Medical Sciences Tehran, Iran.

出版信息

Am J Cardiovasc Dis. 2021 Jun 15;11(3):368-374. eCollection 2021.

PMID:34322306

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8303042/

Abstract

BACKGROUND

Coronary heart disease is the most common cardiovascular worldwide, and some factors can affect the prognosis of this disease. So, in this study, we aimed to examine the relationship between spirometry and cardiovascular risk factors in patients undergoing coronary angiography who were referred to military hospitals.

METHODS

In this cross-sectional study, 200 smokers referred to military hospital for angiography, were enrolled in terms of the inclusion and exclusion criteria between 2019 and 2020. The severity of the coronary artery involvement was determined using Gensini score. The relationship among spirometry and the forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC with other variables including lipid profile, demographic findings, blood pressure, physical activity, and severity of coronary artery involvement were also exanimated.

RESULTS

The frequency of severity of coronary involvement were reported as 3.5% with 25% involvement, 7% with 26-50% involvement, 5.5% with 51-75% involvement, 27.5% with 76-90% involvement, 47% with 91-99% involvement, and 9.5% with 100% involvement. In addition, there was no significant relationship between severity of coronary involvement and FEV1 and FVC (P>0.05). However, there was a significant difference between the groups based on FEV1/FVC (P=0.003), in which the mean of FEV1/FVC was significantly lower in higher severity of coronary involvement compared to lower severity of coronary involvement. There were significant relationships between severity of coronary involvement and body mass index, fasting blood sugar, high-density lipoprotein and low-density lipoprotein, cholesterol, triglyceride, waist circumference, systolic blood pressure, diastolic blood pressure, physical activity, and smoking (P<0.05).

CONCLUSION

There is an association between pulmonary diseases and coronary disease, in which the increased coronary involvement severity is associated with the decreased FEV1/FVC.

摘要

背景

冠心病是全球最常见的心血管疾病，一些因素会影响该疾病的预后。因此，在本研究中，我们旨在探讨在被转诊至军队医院接受冠状动脉造影的患者中，肺功能测定与心血管危险因素之间的关系。

方法

在这项横断面研究中，2019年至2020年期间，根据纳入和排除标准，选取了200名因造影检查而转诊至军队医院的吸烟者。使用Gensini评分确定冠状动脉受累的严重程度。还对肺功能测定以及一秒用力呼气量（FEV1）、用力肺活量（FVC）和FEV1/FVC与其他变量（包括血脂谱、人口统计学结果、血压、身体活动和冠状动脉受累严重程度）之间的关系进行了研究。

结果

冠状动脉受累严重程度的频率报告如下：25%受累为3.5%，26 - 50%受累为7%，51 - 75%受累为5.5%，76 - 90%受累为27.5%，91 - 99%受累为47%，100%受累为9.5%。此外，冠状动脉受累严重程度与FEV1和FVC之间无显著关系（P>0.05）。然而，基于FEV1/FVC，各组之间存在显著差异（P = 0.003），其中冠状动脉受累严重程度较高组的FEV1/FVC平均值显著低于冠状动脉受累严重程度较低组。冠状动脉受累严重程度与体重指数、空腹血糖、高密度脂蛋白和低密度脂蛋白、胆固醇、甘油三酯、腰围、收缩压、舒张压、身体活动和吸烟之间存在显著关系（P<0.05）。