Zhou Liqin, Tang Zhonghua, Zuo Zhentao, Zhou Ke
Cereb Cortex. 2022 Jan 22;32(3):583-592. doi: 10.1093/cercor/bhab235.
Quality sleep is vital for physical and mental health. No matter whether sleep problems are a consequence of or contributory factor to mental disorders, people with psychosis often suffer from severe sleep disturbances. Previous research has shown that acute sleep deprivation (SD) can cause transient brain dysfunction and lead to various cognitive impairments in healthy individuals. However, the relationship between sleep disturbance and bistable perception remains unclear. Here, we investigated whether the bistable perception could be affected by SD and elucidated the functional brain changes accompanying SD effects on bistable perception using functional magnetic resonance imaging. We found that the 28-h SD resulted in slower perceptual transitions in healthy individuals. The reduced perceptual transition was accompanied by the decreased activations in rivalry-related frontoparietal areas, including the right superior parietal lobule, right frontal eye field, and right temporoparietal junction. We speculated that SD might disrupt the normal function of these regions crucial for bistable perception, which mediated the slower rivalry-related perceptual transitions in behavior. Our findings revealed the neural changes underlying the abnormal bistable perception following the SD. It also suggested that SD might offer a new window to understand the neural mechanisms underlying the bistable perception.
优质睡眠对身心健康至关重要。无论睡眠问题是精神障碍的结果还是促成因素，患有精神病的人往往都遭受严重的睡眠障碍。先前的研究表明，急性睡眠剥夺（SD）会导致短暂的脑功能障碍，并在健康个体中引发各种认知障碍。然而，睡眠障碍与双稳态感知之间的关系仍不清楚。在此，我们研究了双稳态感知是否会受到睡眠剥夺的影响，并使用功能磁共振成像阐明了伴随睡眠剥夺对双稳态感知影响的大脑功能变化。我们发现，28小时的睡眠剥夺导致健康个体的感知转换变慢。感知转换的减少伴随着与竞争相关的额顶叶区域激活的减少，包括右侧顶上小叶、右侧额叶眼区和右侧颞顶交界区。我们推测，睡眠剥夺可能会扰乱这些对双稳态感知至关重要的区域的正常功能，从而介导行为中与竞争相关的感知转换变慢。我们的研究结果揭示了睡眠剥夺后异常双稳态感知背后的神经变化。这也表明，睡眠剥夺可能为理解双稳态感知背后的神经机制提供一个新的窗口。
