Tuten Bryan T, Bui Aaron H, Wiedbrauk Sandra, Truong Vinh X, Raston Colin L, Barner-Kowollik Christopher
Centre for Materials Science, School of Chemistry and Physics, Queensland University of Technology (QUT), 2 George Street, Brisbane, QLD 4000, Australia.
Chem Commun (Camb). 2021 Aug 28;57(67):8328-8331. doi: 10.1039/d1cc02984c. Epub 2021 Jul 29.
We introduce a four component Passerini polymerization utilizing sterically bulky isocyanide monomers. Under typical Passerini conditions, bulky isocyanides do not react within standard Passerini reaction timescales (hours). We overcome this challenge via the unique physiochemical conditions present in a vortex fluidic device, reducing the reaction time to 2 h on average. Under these high-shear thin-film conditions, bulky isocyanides are readily incorporated into the multicomponent polymerization without the need of high-pressure or temperature. Finally, we demonstrate that the four component approach using functional cyclic anhydrides allows for post-polymerization modification.
我们介绍了一种利用空间位阻较大的异腈单体的四组分Passerini聚合反应。在典型的Passerini条件下，空间位阻较大的异腈在标准的Passerini反应时间尺度（数小时）内不会发生反应。我们通过涡旋流体装置中存在的独特物理化学条件克服了这一挑战，将反应时间平均缩短至2小时。在这些高剪切薄膜条件下，空间位阻较大的异腈很容易被纳入多组分聚合反应中，而无需高压或高温。最后，我们证明使用功能性环状酸酐的四组分方法允许进行聚合后修饰。
