Ulbricht H
Zentralinstitut für Mikrobiologie und experimentelle Therapie, Akademie der Wissenschaften der DDR, Jena.
Pharmazie. 1987 Sep;42(9):598-601.
2-Amino-oxazoles with the semicyclic amidine structure are able in principle to form hydrogen bonds with native components for example with viral nucleic acids or viral enzymes. In this way the inhibition of viral replication seems to be possible. The syntheses of 39 compounds with amidine structure are described and the results of the antiviral agar diffusion plaque inhibition test are discussed in relation to the chemical structures.
具有半环状脒结构的2-氨基恶唑原则上能够与天然成分,例如病毒核酸或病毒酶形成氢键。通过这种方式,抑制病毒复制似乎是可能的。本文描述了39种具有脒结构的化合物的合成,并结合化学结构讨论了抗病毒琼脂扩散空斑抑制试验的结果。