Dipartimento di Chimica, Università degli Studi di Roma Sapienza, P. le A. Moro 5, I-00185 Rome, Italy.
Inorg Chem. 2021 Aug 16;60(16):12029-12038. doi: 10.1021/acs.inorgchem.1c01195. Epub 2021 Jul 29.
Recent work has been developed on two new classes of neutral porphyrazine complexes of formulas [(PdCl)PyPzM]·HO (PyPz = octakis(2-pyridyl)porphyrazinato anion; M = Mg(HO), Zn, Pd) and [{Pd(CBT)}PyPzM]·HO (M = Mg(HO), Zn; CBT = -carborane-1-thiolate anion). Characterization of all the species has been conducted by IR and UV-visible spectral measurements in a systematic comparison with the corresponding already known mononuclear species [PyPzM] (M = Mg(HO), Zn) and the mono-Pd analogue isolated and presented here for the first time. Comparison includes also the two parent classes of pentanuclear tetrapyrazinoporphyrazines having the more extended π-electron delocalized macrocyclic core PyTPyzPz. The reported new classes of pentanuclear complexes behave as active photosensitizers in photodynamic therapy (PDT), and due to the high boron content of the CBT derivatives, perspectives for them are open of application in the field of bimodal PDT/BNCT (boron neutron capture therapy) anticancer treatments.
最近开发了两类新的中性卟啉嗪配合物，化学式为[(PdCl)PyPzM]·HO（PyPz=八(2-吡啶基)卟啉嗪阴离子；M=Mg(HO)，Zn，Pd）和[{Pd(CBT)}PyPzM]·HO（M=Mg(HO)，Zn；CBT=-咔硼烷-1-硫醇阴离子）。通过与相应的单核配合物[PyPzM]（M=Mg(HO)，Zn）以及首次分离和介绍的单核 Pd 类似物的系统比较，对所有物种进行了红外和紫外可见光谱测量来进行表征。比较还包括具有更扩展的π-电子离域大环核心 PyTPyzPz 的两个母体五核四吡嗪卟啉嗪的前两类。所报道的新的五核配合物类作为光动力治疗（PDT）中的有效光敏剂，并且由于 CBT 衍生物的高硼含量，它们在 PDT/硼中子俘获治疗（BNCT）抗癌治疗的双模态应用方面具有广阔的前景。
