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水凝胶,一种新型的治疗和给药策略,在宫腔粘连的治疗中。

Hydrogel, a novel therapeutic and delivery strategy, in the treatment of intrauterine adhesions.

机构信息

Department of Reproductive Medicine, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.

出版信息

J Mater Chem B. 2021 Sep 7;9(33):6536-6552. doi: 10.1039/d1tb01005k. Epub 2021 Jul 29.

Abstract

Intrauterine adhesions (IUAs) are caused by damage to the underlying lining of the endometrium. They' re related to disorder of endometrial repair. In recent years, hydrogels with controllable biological activity have been widely used for treating IUAs. They encapsulate estrogen, cytokines, cells, or exosomes, forming a delivery system to release therapeutic components for the treatment of IUAs. In addition, the hydrogel acting as a barrier can be degraded in the body automatically, reducing the risk of infection caused by secondary surgeries. In this review, we summarize the recent progress of hydrogels and their application in IUAs as both a novel alternative therapeutic and an artificial delivery strategy.

摘要

宫腔粘连(IUAs)是由子宫内膜下衬里受损引起的。它们与子宫内膜修复障碍有关。近年来,具有可控生物活性的水凝胶已广泛用于治疗 IUAs。它们包封雌激素、细胞因子、细胞或外泌体,形成一个释放治疗成分的输送系统,用于治疗 IUAs。此外,作为屏障的水凝胶可以在体内自动降解,降低因二次手术引起感染的风险。在这篇综述中,我们总结了水凝胶的最新进展及其在 IUAs 中的应用,作为一种新的治疗选择和人工输送策略。

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