Rajabloo Yasamin, Al-Asady Abdulridha Mohammed, Akbarzadeh Hanieh, Avan Amir, Khazaei Majid, Ryzhikov Mikhail, Hassanian Seyed Mahdi
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Sciences, Faculty of Nursing, University of Warith Al-Anbiyaa, Karbala, Iraq.
Curr Pharm Des. 2025;31(13):1057-1066. doi: 10.2174/0113816128348746241030110806.
Intrauterine Adhesions (IUA) are a significant cause of infertility and miscarriage, often resulting from trauma to the endometrium. While hysteroscopic adhesiolysis is the primary treatment, the use of hydrogels as anti-adhesion barriers and drug delivery systems is gaining traction for improving patient outcomes. This review aims to explore various hydrogel types, their role in tissue repair, and the integration of stem cell therapy. Recent advancements in biomaterial scaffolds have demonstrated potential in preventing adhesion recurrence and promoting endometrial regeneration. These emerging treatments provide promising avenues for enhancing the efficacy of traditional therapies in IUA management.
宫腔粘连(IUA)是导致不孕和流产的一个重要原因,通常由子宫内膜创伤引起。虽然宫腔镜粘连松解术是主要治疗方法,但使用水凝胶作为抗粘连屏障和药物递送系统在改善患者预后方面越来越受到关注。本综述旨在探讨各种水凝胶类型、它们在组织修复中的作用以及干细胞治疗的整合。生物材料支架的最新进展已显示出在预防粘连复发和促进子宫内膜再生方面的潜力。这些新兴治疗方法为提高传统疗法在IUA管理中的疗效提供了有前景的途径。