巴西南部住院患者鲍曼不动杆菌复合体的抗生素耐药性四年随访调查。
A four-year follow-up survey of antimicrobial resistance among Acinetobacter baumannii complex from inpatients in Southern Brazil.
机构信息
Sciences of Health Department, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil; Microbiology Department, Qualitá Laboratory, Novo Hamburgo, RS, Brazil.
Toxicology Department, Feevale University, Novo Hamburgo, RS, Brazil.
出版信息
Am J Infect Control. 2021 Dec;49(12):1503-1505. doi: 10.1016/j.ajic.2021.07.014. Epub 2021 Jul 27.
OBJECTIVES
To determine the trends of antimicrobial resistance for Acinetobacter baumannii complex isolates recovered from inpatients over a 4-year follow-up survey.
METHODS
A total of 659 A baumannii complex isolates were recovered from hospitalized patients in Porto Alegre and its metropolitan area, Southern Brazil, from 2017 to 2020. Susceptibility profile was determined for ampicillin/sulbactam, amikacin, gentamicin, imipenem, meropenem, minocycline, polymyxin B and tigecycline.
RESULTS
Overall, PMB was the most active agent against the set of A baumannii isolates over the period. Although stable, a high resistance rate was observed.
CONCLUSIONS
Our results shown the presence of an extensively-drug resistant A baumannii complex isolates over the past four years. Polymyxin B has been the only antimicrobial agent that remain with a good in vitro activity. Strict surveillance and infection control measures are mandatory.
目的
在一项为期 4 年的随访调查中，确定从住院患者中分离出的鲍曼不动杆菌复合体分离株的抗微生物药物耐药趋势。
方法
2017 年至 2020 年，从巴西南里奥格兰德州阿雷格里港及其大都市区的住院患者中分离出 659 株鲍曼不动杆菌复合体分离株。对氨苄西林/舒巴坦、阿米卡星、庆大霉素、亚胺培南、美罗培南、米诺环素、多黏菌素 B 和替加环素进行了药敏试验。
结果
总的来说，多黏菌素 B 是该组鲍曼不动杆菌分离株在整个研究期间最有效的药物。尽管耐药率稳定，但仍很高。
结论
过去四年，我们的研究结果显示了广泛耐药的鲍曼不动杆菌复合体分离株的存在。多黏菌素 B 是唯一一种体外活性良好的抗菌药物。必须严格监测和感染控制措施。
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