瘦素受体信号传导对于完整的低血糖对抗调节是必需的：雄性 Zucker 大鼠的研究。
Leptin receptor signaling is required for intact hypoglycemic counterregulation: A study in male Zucker rats.
机构信息
Neurosignaling Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Neurobiology of Metabolic Dysfunction Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
出版信息
J Diabetes Complications. 2021 Oct;35(10):107994. doi: 10.1016/j.jdiacomp.2021.107994. Epub 2021 Jul 15.
Abstract
Hypoglycemia is a major barrier to clinical management of persons with diabetes. Emerging evidence supports a role for leptin in gating hypoglycemic counterregulation. This work demonstrates that male leptin receptor null, Zucker (fa/fa), rats display severe impairments in hypoglycemic counterregulation. Thus, augmenting leptin levels may have clinical utility for preventing hypoglycemia.
摘要
低血糖是糖尿病患者临床管理的主要障碍。新出现的证据支持瘦素在低血糖拮抗反应中的作用。这项工作表明，雄性瘦素受体缺失型 Zucker（fa/fa）大鼠在低血糖拮抗反应中表现出严重损伤。因此，增加瘦素水平可能具有预防低血糖的临床应用价值。
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