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慢性病毒性肝炎综合管理的进展与挑战:消除的关键途径。

Progress and challenges in the comprehensive management of chronic viral hepatitis: Key ways to achieve the elimination.

机构信息

Department of Gastroenterology and Hepatology, Hospital General de México, Mexico City 06726, Mexico.

Department of Internal Medicine, Hospital General de México, Mexico City 06726, Mexico.

出版信息

World J Gastroenterol. 2021 Jul 14;27(26):4004-4017. doi: 10.3748/wjg.v27.i26.4004.

Abstract

Chronic viral hepatitis is a significant health problem throughout the world, which already represents high annual mortality. By 2040, chronic viral hepatitis due to virus B and virus C and their complications cirrhosis and hepatocellular carcinoma will be more deadly than malaria, vitellogenesis-inhibiting hormone, and tuberculosis altogether. In this review, we analyze the global impact of chronic viral hepatitis with a focus on the most vulnerable groups, the goals set by the World Health Organization for the year 2030, and the key points to achieve them, such as timely access to antiviral treatment of direct-acting antiviral, which represents the key to achieving hepatitis C virus elimination. Likewise, we review the strategies to prevent transmission and achieve control of hepatitis B virus. Finally, we address the impact that the coronavirus disease 2019 pandemic has had on implementing elimination strategies and the advantages of implementing telemedicine programs.

摘要

慢性病毒性肝炎是全球范围内的一个重大健康问题,其每年的死亡率已经很高。到 2040 年,由乙型肝炎病毒和丙型肝炎病毒引起的慢性病毒性肝炎及其并发症肝硬化和肝细胞癌的致死率将超过疟疾、保卵激素和结核病的总和。在这篇综述中,我们分析了慢性病毒性肝炎的全球影响,重点关注最脆弱的群体、世界卫生组织设定的 2030 年目标以及实现这些目标的要点,如及时获得直接作用抗病毒药物的抗病毒治疗,这是实现丙型肝炎病毒消除的关键。同样,我们还回顾了预防乙型肝炎病毒传播和实现控制的策略。最后,我们讨论了 2019 年冠状病毒病大流行对实施消除策略的影响以及实施远程医疗计划的优势。

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