Laboratory of Biochemistry, Immunology and Microbiology (BIM), Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.
Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.
Front Immunol. 2021 Jul 13;12:693054. doi: 10.3389/fimmu.2021.693054. eCollection 2021.
Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8 T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8 T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8 T-cell response against this virus is defective in advanced age, we used an approach to prime SARS-CoV-2-specific naive CD8 T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8 T-cell responses.
高龄与 SARS-CoV-2 感染后的严重症状和死亡相关。病毒特异性 CD8 T 细胞反应已被证明对严重 COVID-19 表现具有保护作用，这表明细胞免疫功能不足可能导致疾病的年龄模式。针对 SARS-CoV-2 等新兴病原体诱导 CD8 T 细胞反应依赖于幼稚 T 细胞的激活。为了研究针对这种病毒的初始 CD8 T 细胞反应是否在高龄时存在缺陷，我们使用一种方法从不同年龄组的健康、未暴露供体中诱导 SARS-CoV-2 特异性幼稚 CD8 T 细胞。与年轻成年人相比，老年人的 SARS-CoV-2 特异性 T 细胞初始刺激能力较差，表现在反应的幅度和质量两方面。此外，老年人识别的表位数量较少。我们的研究结果表明，免疫衰老与 SARS-CoV-2 特异性初始 CD8 T 细胞反应的改变有关。
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