Epidemiology Unit, Department of Prevention, Central Tuscany Local Health Authority, Florence, Italy.
Ann Ig. 2022 Mar-Apr;34(2):150-155. doi: 10.7416/ai.2021.2465. Epub 2021 Apr 30.
Because of the 24 months latency in the release of official data on causes of death, and in consideration of the limited testing capacity during the first pandemic wave, to estimate the COVID-19-related mortality in 2020, the evaluation of all-cause mortality excess is often used instead. Our study aimed at assessing whether in Central Tuscany, Italy, an excess all-cause mortality occurred in the 2019-2020 influenza season, which partly overlapped with the months of the first pandemic wave in which the impact of COVID-19 was the highest.
Age- and sex-adjusted mortality rates for 2019-2020 influenza season were compared with those of influenza seasons 2009-2010 to 2016-2017.
No all-cause mortality excess was observed in the 2019-2020 influenza season, which, on the contrary, was characterized by the lowest all-cause mortality rate.
Our finding can be explained by the imposition, in early March 2020, of a national lockdown, which came into effect in an early epidemic phase in Tuscany, and thus limited the transmission of SARS-CoV-2 infection, as well as influenza, in the territory. In March and April, by causing the death of vulnerable elderly patients who had been spared by the mild seasonal flu in the prior months, COVID-19 acted with a harvesting effect.
由于官方发布的死亡原因数据存在 24 个月的延迟,并且考虑到第一波大流行期间的检测能力有限,为了估计 2020 年的 COVID-19 相关死亡率,通常会评估全因死亡率的超额情况。本研究旨在评估意大利托斯卡纳中部地区在 2019-2020 年流感季节是否发生了全因死亡率超额的情况,该流感季节与 COVID-19 影响最大的第一个大流行浪潮月份部分重叠。
比较了 2019-2020 年流感季节的年龄和性别调整死亡率与 2009-2010 年至 2016-2017 年流感季节的死亡率。
在 2019-2020 年流感季节未观察到全因死亡率超额的情况,相反,该季节的全因死亡率最低。
我们的发现可以解释为 2020 年 3 月初在托斯卡纳实施了全国封锁,这在该地区的大流行早期阶段生效,从而限制了 SARS-CoV-2 感染和流感的传播。在 3 月和 4 月,COVID-19 以收割效应的方式导致了前几个月因轻度季节性流感而幸免的脆弱老年患者死亡。