月球双能 X 射线吸收法（iDXA）测量结直肠癌患者和健康受试者身体成分的精度。
Precision of Lunar Dual-energy X-ray Absorptiometry (iDXA) in measuring body composition among colorectal cancer patients and healthy subjects.
机构信息
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
出版信息
Clin Nutr ESPEN. 2021 Aug;44:316-323. doi: 10.1016/j.clnesp.2021.05.025. Epub 2021 Jun 6.
BACKGROUND & AIMS: High quality and precise methods are needed when monitoring changes in body composition among colorectal cancer (CRC) patients and healthy subjects. The aim of this study was to estimate precision of the Dual-energy X-ray absorptiometry (Lunar iDXA, GE Healthcare software enCORE version 16) in measuring body composition in CRC patients and healthy subjects.
METHODS
Precision error of iDXA in measuring body composition was investigated in the current study. Thirty CRC patients and 30 healthy subjects, including both men and women underwent two consecutive whole-body DXA scan with repositioning. Precision estimates of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in the abdominal region, and total fat mass (FM), fat-free mass (FFM), lean mass (LM), bone mineral density (BMD) and bone mineral content (BMC) were calculated.
RESULTS
Precision error expressed as coefficient of variation (% CV) of VAT and SAT were estimated to be 3.56% and 3.28% among CRC patients, and 5.30% and 3.46% among healthy subjects. Estimated precision errors for body masses in the total region ranged between 0.49-1.01% and 0.40-0.88% in CRC patients and healthy subjects, respectively. Least significant change (LSC) in VAT mass, SAT mass, FM and LM were 140.9 g, 121.4 g, 637.0 g and 701.0 g, respectively, among CRC patients. Among healthy subjects the LSC in VAT, SAT, FM and LM were 80.93 g, 98.90 g, 484.0 g and 618.0 g, respectively. Only minor and non-significant differences between the two consecutive measurements for each body compartment were observed within both populations, and we found no systematic bias in the distribution of the differences.
CONCLUSION
The Lunar iDXA demonstrated high precision in body composition measurements among both CRC patients and healthy subjects. Hence, iDXA is a useful tool in clinical following-up and interventions targeted towards changes in body composition.
背景与目的
在监测结直肠癌（CRC）患者和健康受试者的身体成分变化时，需要使用高质量和精确的方法。本研究的目的是评估双能 X 射线吸收法（Lunar iDXA，GE Healthcare 软件 enCORE 版本 16）测量 CRC 患者和健康受试者身体成分的精密度。
方法
本研究调查了 iDXA 测量身体成分的精密度误差。30 例 CRC 患者和 30 例健康受试者，包括男性和女性，均进行了两次连续的全身 DXA 扫描和重新定位。计算了腹部区域内脏脂肪组织（VAT）和皮下脂肪组织（SAT）以及总脂肪量（FM）、去脂体重（FFM）、瘦体重（LM）、骨矿物质密度（BMD）和骨矿物质含量（BMC）的精密度估计值。
结果
CRC 患者的 VAT 和 SAT 的精密度误差表示为变异系数（%CV）分别为 3.56%和 3.28%，健康受试者分别为 5.30%和 3.46%。CRC 患者和健康受试者的全身各部位体重的精密度误差估计值分别在 0.49-1.01%和 0.40-0.88%之间。CRC 患者的 VAT 质量、SAT 质量、FM 和 LM 的最小有意义变化（LSC）分别为 140.9 g、121.4 g、637.0 g 和 701.0 g。健康受试者的 VAT、SAT、FM 和 LM 的 LSC 分别为 80.93 g、98.90 g、484.0 g 和 618.0 g。在两个群体中，每个身体部位的两次连续测量之间仅观察到较小且无统计学意义的差异，并且我们发现差异分布没有系统偏差。
结论
Lunar iDXA 在 CRC 患者和健康受试者的身体成分测量中具有很高的精密度。因此，iDXA 是临床随访和针对身体成分变化的干预的有用工具。
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