Gotlieb A I, Wong M K, Boden P, Fone A C
Department of Pathology, Faculty of Medicine, University of Toronto, Toronto General Hospital Research Centre, Ontario, Canada.
Scanning Microsc. 1987 Dec;1(4):1715-26.
The injured endothelium undergoes rapid repair of areas of cell desquamation in order to maintain the structural integrity of the endothelial surface. Endothelial repair involves a series of processes which include endothelial cell spreading, translocation, and proliferation. These processes are well defined events which occur sequentially in time. Spreading and translocation are mediated by the cell cytoskeleton--F-actin microfilaments and microtubules and associated centrosomes. The regulation of these processes is complex and is likely due to soluble factors present at the site of injury which are released from activated endothelial cells, platelets, the subendothelial substratum, activated serum factors, and hemodynamic shear stress. Cell replication occurs in order to replace lost cells and maintain the appropriate cell density of the endothelial surface. The factors which regulate endothelial cell proliferation are currently under study.
受损的内皮细胞会对细胞脱屑区域进行快速修复，以维持内皮表面的结构完整性。内皮修复涉及一系列过程，包括内皮细胞铺展、移位和增殖。这些过程是明确的事件，会按时间顺序依次发生。铺展和移位由细胞细胞骨架——F-肌动蛋白微丝、微管及相关中心体介导。这些过程的调节很复杂，可能是由于损伤部位存在的可溶性因子，这些因子由活化的内皮细胞、血小板、内皮下基质、活化的血清因子和血流动力学剪切应力释放。细胞复制是为了替代丢失的细胞并维持内皮表面适当的细胞密度。目前正在研究调节内皮细胞增殖的因子。
